VEGF Signaling Pathway

Ras Raf MEK1/2 ERK1/2 VEGF PKC VEGFR2 PLCγ PGI₂ FAK p38 MAPK eNOS Caspase Rac Akt Bad PI3K Src Angiogenesis Calcium

The VEGF (vascular endothelial growth factor) signaling pathway regulates vascular development in the embryo (vasculogenesis) and new blood vessel formation (angiogenesis). The VEGFR can induce several cellular processes which are common to many growth factor receptors, including cell migration, proliferation and survival.

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Signaling Pathway Key

Stimulates

Inhibits

Multistep Activation

Kinase

Enzyme-linked Receptor

Other Enzyme

Other Protein

Proapoptotic