VEGF Signaling Pathway
Ras Raf MEK1/2 ERK1/2 VEGF PKC VEGFR2 PLCγ PGI2 FAK p38 MAPK eNOS Caspase Rac Akt Bad PI3K Src Angiogenesis Calcium
The VEGF (vascular endothelial growth factor) signaling pathway regulates vascular development in the embryo (vasculogenesis) and new blood vessel formation (angiogenesis). The VEGFR can induce several cellular processes which are common to many growth factor receptors, including cell migration, proliferation and survival.
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Signaling Pathway Key
Stimulates
Inhibits
Multistep Activation
Kinase
Enzyme-linked Receptor
Other Enzyme
Other Protein
Proapoptotic
