Caspases (cysteinyl aspartate proteases) are involved in the signaling pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules.
Inhibitors |
Cat. No. | Product Name / Activity |
---|---|
2166 | Z-DEVD-FMK |
Cell-permeable, irreversible caspase-3 inhibitor | |
6172 | INF 4E |
Caspase-1 and NLRP3 inflammasome inhibitor | |
2163 | Z-VAD-FMK |
Cell-permeable, irreversible caspase inhibitor | |
7143 | VX 765 New |
High affinity and selective caspase-4 and caspase 1/ICE inhibitor; orally bioavailable | |
Activators |
Cat. No. | Product Name / Activity |
2251 | Cisplatin |
Potent pro-apoptotic anticancer agent; activates caspase-3 | |
3590 | Gambogic acid |
Apoptosis inducer. Activates caspases | |
2581 | PAC 1 |
Activator of procaspase-3; pro-apoptotic | |
1758 | PETCM |
Activator of caspase-3 | |
Other |
Cat. No. | Product Name / Activity |
2098 | Apoptosis Activator 2 |
Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis |
Caspases (cysteinyl aspartate proteases) are involved in the signal transduction pathways of apoptosis, necrosis and inflammation. These enzymes can be divided into two major classes - initiators and effectors. The initiator isoforms (caspases-1,-4,-5,-8,-9,-10,-11,-12) are activated by, and interact with, upstream adaptor molecules through protein-protein interaction domains known as CARD and DED.
Effector caspases (-3,-6,-7) are responsible for cleaving downstream substrates and are sometimes referred to as the executioner caspases. More than 700 caspase substrates have so far been identified (see The Caspase Substrate Database).
Initiator caspases, such as caspase 8, may be directly activated by death receptors such as FasR. Caspases can also be found intracellularly as part of large multiprotein complexes. For example, caspase 9 is recruited to the apoptosome formed during apoptosis, whilst caspases-1 and 5 can form part of the inflammasome, a key part of cytokine processing during inflammation.
Caspases are regulated by inhibitors of apoptosis and by dominant negative isoforms. They have been implicated in the pathogenesis of many disorders including stroke, Alzheimer's disease, myocardial infarction, cancer, and inflammatory disease.
Tocris offers the following scientific literature for Caspases to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Gene | Species | Gene Symbol | Gene Accession No. | Protein Accession No. |
---|---|---|---|---|
Cytokine Processing Caspases | ||||
Caspase 1 | Human | CASP1 | NM_033292 | P29466 |
Mouse | Casp1 | NM_009807 | P29452 | |
Rat | Casp1 | NM_012762 | Q91W32 | |
Caspase 4 | Human | CASP4 | NM_001225 | P49662 |
Mouse | Casp4 | NM_007609 | P70343 | |
Rat | Casp4 | NM_053736 | Q3MHS1 | |
Caspase 5 | Human | CASP5 | NM_004347 | P51878 |
Caspase 11 | Human | SFRS2IP | NM_004719 | Q99590 |
Mouse | Sfrs2ip | NM_028148 | NP_082424 | |
Rat | Sfrs2ip | XM_231361 | XP_231361 | |
Caspase 12 | Human | CASP12 | NR_000035 | Q6UXS9 |
Mouse | Casp12 | NM_009808 | O08736 | |
Rat | Casp12 | NM_130422 | Q920D5 | |
Caspase 14 | Human | CASP14 | NM_012114 | P31944 |
Mouse | Casp14 | NM_009809 | O89094 | |
Rat | Casp14 | XM_234878 | XP_234878 | |
Apoptosis-Related Caspases | ||||
Caspase 2 | Human | CASP2 | NM_032982 | P42575 |
Mouse | Casp2 | NM_007610 | P29594 | |
Rat | Casp2 | NM_022522 | P55215 | |
Caspase 3 | Human | CASP3 | NM_004346 | P42574 |
Mouse | Casp3 | NM_009810 | P70677 | |
Rat | Casp3 | NM_012922 | P55213 | |
Caspase 6 | Human | CASP6 | NM_001226 | P55212 |
Mouse | Casp6 | NM_009811 | O08738 | |
Rat | Casp6 | NM_031775 | Q6AZ23 | |
Caspase 7 | Human | CASP7 | NM_033338 | P55210 |
Mouse | Casp7 | NM_007611 | P97864 | |
Rat | Casp7 | NM_022260 | O88550 | |
Caspase 8 | Human | CASP8 | NM_001228 | Q96T22 |
Mouse | Casp8 | NM_009812 | O89110 | |
Rat | Casp8 | NM_022277 | Q9JHX4 | |
Caspase 9 | Human | CASP9 | NM_032996 | P55211 |
Mouse | Casp9 | NM_015733 | NP_056548 | |
Rat | Casp9 | NM_031632 | Q9JHK1 | |
Caspase 10 | Human | CASP10 | NM_032977 | Q92851 |