SK 216

Pricing Availability   Qty
Description: Plasminogen activator inhibitor-1 (PAI-1) inhibitor
Chemical Name: 2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for SK 216

SK 216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor. Inhibits VEGF-induced migration and tube formation in HUVECs. Also attenuates TGF-β dependent epithelial-mesenchymal transition and fibroblast to myofibroblast differentiation in vitro. Reduces size and weight of subcutaneous tumors, and inhibits metastasis and angiogenesis in vivo. Reduces bleomycin-induced pulmonary fibrosis in vivo. Orally bioavailable.

Technical Data for SK 216

M. Wt 533.52
Formula C29H29NO6Na2
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 654080-03-2
PubChem ID 131954585
Smiles CC(C)(C)C1=CC=C(OC(C2=CC(C=CC(OCCCCCC(C(O[Na])=O)C(O[Na])=O)=C3)=C3C=C2)=N4)C4=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SK 216

Solvent Max Conc. mg/mL Max Conc. mM
water 2.67 5 with gentle warming

Preparing Stock Solutions for SK 216

The following data is based on the product molecular weight 533.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 37.49 mL 187.43 mL 374.87 mL
0.25 mM 7.5 mL 37.49 mL 74.97 mL
0.5 mM 3.75 mL 18.74 mL 37.49 mL
2.5 mM 0.75 mL 3.75 mL 7.5 mL

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References for SK 216

References are publications that support the biological activity of the product.

Omori et al (2016) Inhibition of plasminogen activator inhibitor-1 attenuates transforming growth factor-β-dependent epithelial mesenchymal transition and differentiation of fibroblasts to myofibroblasts. PLoS One. 11 e0148969 PMID: 26859294

Takayama et al (2016) Inhibition of PAI-1 limits tumor angiogenesis regardless of angiogenic stimuli in malignant pleural mesothelioma. Cancer Res. 76 3285 PMID: 27197170

Masuda et al (2013) SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis. Mol.Cancer Ther. 12 2378 PMID: 23990114

If you know of a relevant reference for SK 216, please let us know.

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Keywords: SK 216, SK 216 supplier, SK216, plasminogen, activator, inhibitor-1, inhibitors, inhibits, PAI-1, angiogenesis, antiangiogenesis, Mesenchymal, Stem, Cells, Antiangiogenics, Plasminogen, Activator, Inhibitor, 1, 6187, Tocris Bioscience

Citations for SK 216

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.