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Adenosine A2B receptor positive allosteric modulator. Potentiates the NECA (Cat. No. 1691) -induced increase in cAMP production in CHO cells expressing A2B receptors. Also potentiates the effects of NECA and the A2B receptor agonist BAY 60-6583 (Cat. No. 4472) in mediating osteoblast differentiation from MSCs in vitro.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 354.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.64 mL||28.22 mL||56.43 mL|
|2.5 mM||1.13 mL||5.64 mL||11.29 mL|
|5 mM||0.56 mL||2.82 mL||5.64 mL|
|25 mM||0.11 mL||0.56 mL||1.13 mL|
References are publications that support the biological activity of the product.
Trincavelli et al (2014) Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim.Biophys.Acta 1843 2957 PMID: 25241343
Trincavelli et al (2014) Allosteric modulators of human A2B adenosine receptor. Biochim.Biophys.Acta 1840 1194 PMID: 24361612
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Keywords: KI-7, KI-7 supplier, adenosine, A2B, receptor, positive, allosteric, modulators, PAMs, modulates, mesenchymal, stem, cells, MSCs, osteoblast, differentiation, Adenosine, Receptors, Mesenchymal, Stem, Cells, 6787, Tocris Bioscience
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