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Biological Activity for KI-7
KI-7 is an adenosine A2B receptor positive allosteric modulator. Potentiates the NECA (Cat. No. 1691) -induced increase in cAMP production in CHO cells expressing A2B receptors. Also potentiates the effects of NECA and the A2B receptor agonist BAY 60-6583 (Cat. No. 4472) in mediating osteoblast differentiation from MSCs in vitro.
Compound Libraries for KI-7
Technical Data for KI-7
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for KI-7
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for KI-7
The following data is based on the product molecular weight 354.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.64 mL||28.22 mL||56.43 mL|
|2.5 mM||1.13 mL||5.64 mL||11.29 mL|
|5 mM||0.56 mL||2.82 mL||5.64 mL|
|25 mM||0.11 mL||0.56 mL||1.13 mL|
References for KI-7
References are publications that support the biological activity of the product.
Trincavelli et al (2014) Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim.Biophys.Acta 1843 2957 PMID: 25241343
Trincavelli et al (2014) Allosteric modulators of human A2B adenosine receptor. Biochim.Biophys.Acta 1840 1194 PMID: 24361612
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Keywords: KI-7, KI-7 supplier, adenosine, A2B, receptor, positive, allosteric, modulators, PAMs, modulates, mesenchymal, stem, cells, MSCs, osteoblast, differentiation, Adenosine, Receptors, Mesenchymal, Stem, Cells, 6787, Tocris Bioscience
Citations for KI-7
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Literature in this Area
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