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Discontinued Product
6787 has been discontinued.
View all Adenosine A<sub>2B</sub> Receptors products.
Description: Positive allosteric modulator of A2B receptors
Chemical Name: α-Oxo-N-phenyl-1-(phenylmethyl)-1H-indole-3-acetamide
Purity: ≥98% (HPLC)
Biological Activity for KI-7
KI-7 is an adenosine A2B receptor positive allosteric modulator. Potentiates the NECA (Cat. No. 1691) -induced increase in cAMP production in CHO cells expressing A2B receptors. Also potentiates the effects of NECA and the A2B receptor agonist BAY 60-6583 (Cat. No. 4472) in mediating osteoblast differentiation from MSCs in vitro.
Compound Libraries for KI-7
KI-7 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for KI-7
| M. Wt | 354.4 |
| Formula | C23H18N2O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1489263-00-4 |
| PubChem ID | 73350966 |
| InChI Key | MQMGZFRIEZRHHJ-UHFFFAOYSA-N |
| Smiles | O=C(C(C1=CN(C2=CC=CC=C12)CC3=CC=CC=C3)=O)NC4=CC=CC=C4 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for KI-7
References for KI-7
References are publications that support the biological activity of the product.
Trincavelli et al (2014) Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim.Biophys.Acta 1843 2957 PMID: 25241343
Trincavelli et al (2014) Allosteric modulators of human A2B adenosine receptor. Biochim.Biophys.Acta 1840 1194 PMID: 24361612
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Keywords: KI-7, KI-7 supplier, adenosine, A2B, receptor, positive, allosteric, modulators, PAMs, modulates, mesenchymal, stem, cells, MSCs, osteoblast, differentiation, Adenosine, Receptors, Mesenchymal, Stem, Cells, 6787, Tocris Bioscience
Citations for KI-7
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Currently there are no citations for KI-7.
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