KI-7

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Cat.No. 6787 - KI-7 | C23H18N2O2 | CAS No. 1489263-00-4
Description: Positive allosteric modulator of A2B receptors
Chemical Name: α-Oxo-N-phenyl-1-(phenylmethyl)-1H-indole-3-acetamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Adenosine A2B receptor positive allosteric modulator. Potentiates the NECA (Cat. No. 1691) -induced increase in cAMP production in CHO cells expressing A2B receptors. Also potentiates the effects of NECA and the A2B receptor agonist BAY 60-6583 (Cat. No. 4472) in mediating osteoblast differentiation from MSCs in vitro.

Technical Data

M. Wt 354.4
Formula C23H18N2O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1489263-00-4
PubChem ID 73350966
InChI Key MQMGZFRIEZRHHJ-UHFFFAOYSA-N
Smiles O=C(C(C1=CN(C2=CC=CC=C12)CC3=CC=CC=C3)=O)NC4=CC=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.72 50

Preparing Stock Solutions

The following data is based on the product molecular weight 354.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.64 mL 28.22 mL 56.43 mL
2.5 mM 1.13 mL 5.64 mL 11.29 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
25 mM 0.11 mL 0.56 mL 1.13 mL

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References

References are publications that support the biological activity of the product.

Trincavelli et al (2014) Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim.Biophys.Acta 1843 2957 PMID: 25241343

Trincavelli et al (2014) Allosteric modulators of human A2B adenosine receptor. Biochim.Biophys.Acta 1840 1194 PMID: 24361612


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Keywords: KI-7, KI-7 supplier, adenosine, A2B, receptor, positive, allosteric, modulators, PAMs, modulates, mesenchymal, stem, cells, MSCs, osteoblast, differentiation, Adenosine, Receptors, Mesenchymal, Stem, Cells, 6787, Tocris Bioscience

Citations for KI-7

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