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Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.
Kartogenin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 317.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.15 mL||15.76 mL||31.51 mL|
|5 mM||0.63 mL||3.15 mL||6.3 mL|
|10 mM||0.32 mL||1.58 mL||3.15 mL|
|50 mM||0.06 mL||0.32 mL||0.63 mL|
References are publications that support the biological activity of the product.
Johnson et al (2012) A stem cell-based approach to cartilage repair. Science 336 717 PMID: 22491093
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Keywords: Kartogenin, Kartogenin supplier, Supplier, mesenchymal, stem, cell, differentiation, differentiators, potently, inducers, chondrocytes, cartilage, osteoarthritis, Mesenchymal, Stem, Cells, 4513, Tocris Bioscience
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Added to culture medium on days 1-3 at 10 µM to induced chondrogenic differentiation in an immortalized hBMSC cell line. After 7 days there was increased sulfated GAG production compared to basic controls and increased DNA yield compared to cells cultured in traditional chondrogenic differentiation medium.
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.