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Submit ReviewKartogenin
Description: Potently induces chondrogenesis in MSCs
Chemical Name: 2-[((1,1'-Biphenyl)-4-ylamino)carbonyl]benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for Kartogenin
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.
Compound Libraries for Kartogenin
Kartogenin is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for Kartogenin
| M. Wt | 317.34 |
| Formula | C20H15NO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 4727-31-5 |
| PubChem ID | 2826191 |
| InChI Key | SLUINPGXGFUMLL-UHFFFAOYSA-N |
| Smiles | O=C(NC2=CC=C(C3=CC=CC=C3)C=C2)C1=CC=CC=C1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Kartogenin
References for Kartogenin
References are publications that support the biological activity of the product.
Johnson et al (2012) A stem cell-based approach to cartilage repair. Science 336 717 PMID: 22491093
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Citations for Kartogenin
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Currently there are no citations for Kartogenin.
Reviews for Kartogenin
Average Rating: 5 (Based on 1 Review.)
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Chondrogenic differentiation of human bone marrow stromal cells.
By
Nicola Foster on 08/28/2020
Assay Type: In Vitro
Species: Human
Added to culture medium on days 1-3 at 10 µM to induced chondrogenic differentiation in an immortalized hBMSC cell line. After 7 days there was increased sulfated GAG production compared to basic controls and increased DNA yield compared to cells cultured in traditional chondrogenic differentiation medium.
Literature in this Area
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Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.