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Antiangiogenics

Antiangiogenic agents are compounds which prevent angiogenesis in vitro and/or in vivo. Angiogenesis inhibitors may be endogenous or synthetic; others are obtained from diet, for example resveratrol.

Products
Literature (2)

Inhibitors
Cat. No. Product Name / Activity
6840 AD 01
FKBPL (FK506-binding protein like)-based peptide; inhibits breast cancer stem cell self-renewal; also antiangiogenic
6305 Lenalidomide
Angiogenesis inhibitor; also TNF-α inhibitor and cereblon binder
6302 Pomalidomide
Antiangiogenic; also TNF-α inhibitor and cereblon ubiquitination inhibitor
6187 SK 216
Angiogenesis inhibitor; Also PAI-1 inhibitor

Other
Cat. No. Product Name / Activity
5121 3PO
PFKFB3 inhibitor; antiangiogenic
5617 AZD 1480
Potent and selective JAK2 inhibitor; antiangiogenic
4706 Borrelidin
Antiangiogenic; inhibits threonyl-tRNA synthetase
5029 CHC
Monocarboxylic acid transport (MCT) inhibitor; displays anti-angiogenic activities
1768 Fumagillin
Antiangiogenic
1629 Herbimycin A
Antiangiogenic. Inhibits Src family kinases and Hsp90
5981 Itraconazole
SMO antagonist; antiangiogenic
5260 KG 5
Antiangiogenic; PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
1461 Linomide
Immunomodulator with antiangiogenic properties
1807 2-Methoxyestradiol
Antiangiogenic and apoptotic agent
4664 Obtustatin
Potent and selective α1β1 inhibitor; antiangiogenic
2710 OGT 2115
Antiangiogenic. Heparanase inhibitor
4733 P005091
USP7 inhibitor; antiangiogenic
4744 P11
Potent antagonist of αvβ3-vitronectin interaction; antiangiogenic
2954 PX 12
Thioredoxin-1 inhibitor; attenuates expression of HIF-1α
4885 R 1530
Multi-RTK inhibitor; inhibits angiogenesis
1418 Resveratrol
Cyclooxygenase inhbitor
0652 Thalidomide
Antiangiogenic; also inhibits TNF-α synthesis
1098 Tranilast
Antiangiogenic
4988 Vialinin A
Inhibits VEGF-induced neovascularization; also inhibits USP4 and USP5/IsoT

Literature for Antiangiogenics

Tocris offers the following scientific literature for Antiangiogenics to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.