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Description: MCT inhibitor; decreases glycoloysis
Chemical Name: 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
Purity: ≥98% (HPLC)
Biological Activity for CHC
CHC is a monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide (Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.
Compound Libraries for CHC
CHC is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CHC
| M. Wt | 189.17 |
| Formula | C10H7NO3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 28166-41-8 |
| PubChem ID | 5328791 |
| InChI Key | AFVLVVWMAFSXCK-VMPITWQZSA-N |
| Smiles | OC1=CC=C(/C=C(C#N)/C(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CHC
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.92 | 100 | |
| ethanol | 3.78 | 20 |
Preparing Stock Solutions for CHC
The following data is based on the product molecular weight 189.17. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.29 mL | 26.43 mL | 52.86 mL |
| 5 mM | 1.06 mL | 5.29 mL | 10.57 mL |
| 10 mM | 0.53 mL | 2.64 mL | 5.29 mL |
| 50 mM | 0.11 mL | 0.53 mL | 1.06 mL |
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Product Datasheets for CHC
References for CHC
References are publications that support the biological activity of the product.
Miranda-Gonçalves et al (2013) Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. Neuro.Oncol. 15 172 PMID: 23258846
Fang et al (2006) The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol.Pharmacol. 70 2108 PMID: 17000864
Dimmer et al (2000) The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem.J. 350 219 PMID: 10926847
Colen et al (2006) Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. Neurosurgery 59 1313 PMID: 17277695
If you know of a relevant reference for CHC, please let us know.
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Keywords: CHC, CHC supplier, a-cyano-4-OH-cinnamate, alpha-cyano-4-OH-cinnamate, CHC, monocarboxylic, acid, monocarboxylate, transporters, MCT, inhibitors, inhibits, lactate, pyruvate, glycolytic, metabolism, gliomas, antiangiogenesis, antitumoral, ACCA, á-cyano-4-hydroxy-cinnamic, Antiangiogenics, Monocarboxylate, Transporters, 5029, Tocris Bioscience
1 Citation for CHC
Citations are publications that use Tocris products. Selected citations for CHC include:
Jang et al (2016) A branched-chain amino acid metabolite drives vascular fatty acid transport and causes Ins resistance. Nat Med 22 421 PMID: 26950361
Do you know of a great paper that uses CHC from Tocris? Please let us know.
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Literature in this Area
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Cancer Research Product Guide
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Angiogenesis
- Invasion and Metastasis