CHC

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Cat.No. 5029 - CHC | C10H7NO3 | CAS No. 28166-41-8
Description: MCT inhibitor; decreases glycoloysis
Chemical Name: 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
Purity: ≥98% (HPLC)
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Biological Activity

Monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide (Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.

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Technical Data

M. Wt 189.17
Formula C10H7NO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 28166-41-8
PubChem ID 5328791
InChI Key AFVLVVWMAFSXCK-VMPITWQZSA-N
Smiles OC1=CC=C(/C=C(C#N)/C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.92 100
ethanol 9.46 50

Preparing Stock Solutions

The following data is based on the product molecular weight 189.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.29 mL 26.43 mL 52.86 mL
5 mM 1.06 mL 5.29 mL 10.57 mL
10 mM 0.53 mL 2.64 mL 5.29 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Miranda-Gonçalves et al (2013) Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets. Neuro.Oncol. 15 172 PMID: 23258846

Fang et al (2006) The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol.Pharmacol. 70 2108 PMID: 17000864

Dimmer et al (2000) The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochem.J. 350 219 PMID: 10926847

Colen et al (2006) Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study. Neurosurgery 59 1313 PMID: 17277695


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