PX 12

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Cat.No. 2954 - PX 12 | C7H12N2S2 | CAS No. 141400-58-0
Description: Thioredoxin-1 inhibitor
Alternative Names: IV-2
Chemical Name: 2-[(1-Methylpropyl)dithio]-1H-imidazole
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.

Technical Data

M. Wt 188.31
Formula C7H12N2S2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 141400-58-0
PubChem ID 219104
InChI Key BPBPYQWMFCTCNG-UHFFFAOYSA-N
Smiles CC(CC)SSC1=NC=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 188.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.31 mL 26.55 mL 53.1 mL
5 mM 1.06 mL 5.31 mL 10.62 mL
10 mM 0.53 mL 2.66 mL 5.31 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kirkpatrick et al (1998) Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides. Biochem.Pharmacol. 55 987 PMID: 9605422

Welsh et al (2003) The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation. Mol.Cancer.Ther. 2 235 PMID: 12657718

Jordan et al (2005) The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin.Cancer Res. 11 529 PMID: 15701837


If you know of a relevant reference for PX 12, please let us know.

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Keywords: px12 thioredoxin-1 trx-1 inhibitors inhibits HIF-1alpha HIF-1a HIF-1α IV-2 antiangiogenics IV-2 Other Reductase

1 Citation for PX 12

Citations are publications that use Tocris products. Selected citations for PX 12 include:

Zhu et al (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. Cell Death Differ 31 31 PMID: 22463935


Do you know of a great paper that uses PX 12 from Tocris? If so please let us know.

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