Thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 188.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.31 mL||26.55 mL||53.1 mL|
|5 mM||1.06 mL||5.31 mL||10.62 mL|
|10 mM||0.53 mL||2.66 mL||5.31 mL|
|50 mM||0.11 mL||0.53 mL||1.06 mL|
References are publications that support the biological activity of the product.
Kirkpatrick et al (1998) Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides. Biochem.Pharmacol. 55 987 PMID: 9605422
Welsh et al (2003) The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation. Mol.Cancer.Ther. 2 235 PMID: 12657718
Jordan et al (2005) The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin.Cancer Res. 11 529 PMID: 15701837
If you know of a relevant reference for PX 12, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PX 12, PX 12 supplier, px12, thioredoxin-1, trx-1, inhibitors, inhibits, HIF-1alpha, HIF-1a, HIF-1α, IV-2, antiangiogenics, Antiangiogenics, Hypoxia, Inducible, Factors, TrxR, 2954, Tocris Bioscience
2 Citations for PX 12
Citations are publications that use Tocris products. Selected citations for PX 12 include:
Zhu et al (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. Cell Death Differ 31 31 PMID: 22463935
Shin et al (2013) PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion. Oncol Lett 6 1804 PMID: 24260080
Do you know of a great paper that uses PX 12 from Tocris? Please let us know.
Reviews for PX 12
There are currently no reviews for this product. Be the first to review PX 12 and earn rewards!
Have you used PX 12?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.