AZD 1480

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Description: Potent and selective JAK2 inhibitor; antiangiogenic
Chemical Name: 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews
Pathways (1)

Biological Activity for AZD 1480

AZD 1480 is a potent and selective JAK2 inhibitor (IC50 < 3 nM). Exhibits >50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo.

Compound Libraries for AZD 1480

AZD 1480 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 1480

M. Wt 348.77
Formula C14H14ClFN8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 935666-88-9
PubChem ID 16659841
InChI Key PDOQBOJDRPLBQU-QMMMGPOBSA-N
Smiles C[C@@H](C1=NC=C(F)C=N1)NC2=NC=C(Cl)C(NC3=NNC(C)=C3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for AZD 1480

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.88 100
ethanol 34.88 100

Preparing Stock Solutions for AZD 1480

The following data is based on the product molecular weight 348.77. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.34 mL 28.67 mL
5 mM 0.57 mL 2.87 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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References for AZD 1480

References are publications that support the biological activity of the product.

Ioannidis S et al (2011) Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. J.Med.Chem. 54 262 PMID: 21138246

Xin et al (2011) Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 71 6601 PMID: 21920898


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View Related Products by Product Action

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Keywords: AZD 1480, AZD 1480 supplier, AZD1480, JAK2, inhibitors, cancer, anticancers, metastasis, angiogenesis, STAT3, signaling, potent, selective, inhibits, JAK, Antiangiogenics, Kinase, 5617, Tocris Bioscience

2 Citations for AZD 1480

Citations are publications that use Tocris products. Selected citations for AZD 1480 include:

John D et al (2021) Nitric Oxide Induces a Janus Kinase-1-Dependent Inflammatory Response in Primary Murine Astrocytes. ASN Neuro 13 17590914211033650 PMID: 34498493

Maarten H et al (2020) Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells. Biochem Biophys Rep 24 100832 PMID: 33102814


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Pathways for AZD 1480

JAK-STAT Signaling Pathway

JAK-STAT Signaling Pathway

The JAK-STAT signaling pathway has several roles, including the control of cell proliferation and hematopoiesis. It is the main signal transduction cascade from cytokine receptors.