AZD 1480

Pricing Availability Delivery Time Qty
Cat.No. 5617 - AZD 1480 | C14H14ClFN8 | CAS No. 935666-88-9
Description: Potent and selective JAK2 inhibitor; antiangiogenic
Chemical Name: 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine
Purity: ≥98% (HPLC)

Biological Activity

Potent and selective JAK2 inhibitor (IC50 < 3 nM). Exhibits >50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo.

Compound Libraries

AZD 1480 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 348.77
Formula C14H14ClFN8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 935666-88-9
PubChem ID 16659841
Smiles C[C@@H](C1=NC=C(F)C=N1)NC2=NC=C(Cl)C(NC3=NNC(C)=C3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.88 100
ethanol 34.88 100

Preparing Stock Solutions

The following data is based on the product molecular weight 348.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.87 mL 14.34 mL 28.67 mL
5 mM 0.57 mL 2.87 mL 5.73 mL
10 mM 0.29 mL 1.43 mL 2.87 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Ioannidis S et al (2011) Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway. J.Med.Chem. 54 262 PMID: 21138246

Xin et al (2011) Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. Cancer Res. 71 6601 PMID: 21920898

If you know of a relevant reference for AZD 1480, please let us know.

View Related Products by Target

View Related Products by Product Action

View all JAK Kinase Inhibitors

Keywords: AZD1480 JAK2 inhibitors cancer anticancers metastasis angiogenesis STAT3 signaling potent selective inhibits JAK Kinase

Citations for AZD 1480

Citations are publications that use Tocris products.

Currently there are no citations for AZD 1480. Do you know of a great paper that uses AZD 1480 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area

Pathways for AZD 1480


TODO: Add Protocols