Cancer Research

Cancer is a term used to define a group of diseases in which abnormal cells divide without control, are able to invade neighboring tissues/organs and metastasize. Cancer has been characterized by six hallmarks; self sufficiency in proliferative growth signals, insensitivity to growth inhibitors, evasion of apoptosis, limitless replicative potential, ability to develop blood vessels (angiogenesis), and tissue invasion and metastasis.

Cancer Research Product Areas

Cancer Types

There are more than 100 different types of human cancer - most named after the organ or type of cell in which they start. Cancer types can be grouped into broad categories, the five main ones being:

  • Carcinoma - cancer that begins in the skin or in tissues that line internal organs.
  • Sarcoma - cancer that begins in connective or supportive tissue (bone, cartilage, muscle).
  • Leukemia - cancer that starts in blood-forming tissue such as the bone marrow. Abnormal blood cells are produced which enter the bloodstream.
  • Lymphoma and myeloma - cancers that begin in the immune system.
  • CNS cancers - cancers that begin in the tissues of the brain and spinal cord.
Therapeutics

Due to the prevalence of cancer within the population, investigation of potential therapeutic targets is the focus of intense research. Current therapeutic research is focusing on identifying new cellular targets for intervention, developing drugs based on small molecules, antibodies or nucleic acids. New drugs specifically targeting intracellular kinases, growth factor receptors or the proteasome are beginning to be used as frontline therapies, often in combination with established chemotherapeutic agents.

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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MAPK Signaling Review

Written by E. Zaganjor & M. Cobb

MAPK Signaling Scientific Review

Our MAPK signaling review gives an overview of the MAPK signaling cascade and summarizes small molecule inhibitors of the pathway. Request copy or view PDF today.

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Autophagy Review

Written by P. Boya & P. Codogno

Autophagy Scientific Review

Our Autophagy review summarizes the molecular mechanisms and physiology of autophagy, as well as the role of autophagy in certain disease states. Request copy or view PDF today.

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Epigenetics Research Bulletin

The epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets. View PDF today.

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Autophagy: Mechanisms and Function

Written by Patricia Boya and Patrice Codogno

Autophagy Life Science Poster

Our Autophagy poster summarizes the molecular machinery, physiology and pathology of autophagy, and highlights chemical compounds that modulate autophagy. Request copy or view PDF today.

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Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

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The p53 Tumor Suppressor Response

Written by Christopher J. Brown et al

p53 Life Science Poster

A summary of the main strategies for the reactivation of p53, including small molecules and peptides, which act to stabilize p53 to rescue wild-type activity. Request copy today.

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Akt Pathway

Akt Signaling Pathway

Akt signaling is involved in fundamental cellular processes such as protein synthesis, metabolism, proliferation and survival. View pathway or download PDF today.

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Apoptosis Pathway

Apoptosis Signaling Pathway

Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.

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MAPK Pathway

MAPK Signaling Pathway

The MAPK family kinases respond to extracellular stimuli such as heat and stress to mediate intracellular signals. View pathway or download PDF today.

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mTOR Pathway

mTOR Signaling Pathway

The mTOR complexes (mTORC1 and 2) respond to intra- and extracellular signals to mediate cell growth, proliferation and survival. View pathway or download PDF today.

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p53 Pathway

p53 Signaling Pathway

Signals through the p53 pathway are integral in the control of the cellular response different types of stress. View pathway or download PDF today.

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VEGF Pathway

VEGF Signaling Pathway

VEGF signaling regulates vascular development (vasculogenesis) and the formation of new blood vessels (angiogenesis). View pathway or download PDF today.

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