RAS Oncoproteins Scientific Review

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RAS Oncoproteins Scientific Review

Therapeutic Vulnerabilities

Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der

Review Exerpt: The three human RAS genes (HRAS, KRAS and NRAS) encode four highly related RAS small GTPases (HRAS, KRAS4A, KRAS4B and NRAS). RAS proteins function as GDP-GTP regulated binary on-off switches that regulate a diverse network of cytoplasmic signaling networks. In cancer and developmental disorders (RASopathies) mutationally activated RAS proteins drive aberrant signal transduction.