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The RAS Oncoproteins Scientific Review is part of the range of scientific reviews and bulletins produced by Tocris and written by leading experts summarizing the most recent developments in research and available products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der
Review Exerpt: The three human RAS genes (HRAS, KRAS and NRAS) encode four highly related RAS small GTPases (HRAS, KRAS4A, KRAS4B and NRAS). RAS proteins function as GDP-GTP regulated binary on-off switches that regulate a diverse network of cytoplasmic signaling networks. In cancer and developmental disorders (RASopathies) mutationally activated RAS proteins drive aberrant signal transduction.