TC E3 5031

Pricing Availability Delivery Time Qty
Cat.No. 6466 - TC E3 5031 | C15H12N2O7 | CAS No. 1061605-21-7
Description: Functionalized cereblon ligand for PROTACs
Chemical Name: 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Derivative of Thalidomide (Cat.No. 0652), commonly used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.

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Technical Data

M. Wt 332.26
Formula C15H12N2O7
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1061605-21-7
PubChem ID 25015436
InChI Key ZVWIXIGBWIEDFO-UHFFFAOYSA-N
Smiles O=C(N1C(CC2)C(NC2=O)=O)C3=C(C1=O)C(OCC(O)=O)=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 332.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.01 mL 15.05 mL 30.1 mL
5 mM 0.6 mL 3.01 mL 6.02 mL
10 mM 0.3 mL 1.5 mL 3.01 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lohbeck and Miller (2016) Practical synthesis of a phthalimide-based cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 26 5260 PMID: 27687673


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Keywords: TC E3 5031, supplier, PROTACs, thalidomide, PROteolysis, TArgeting, Chimeras, cereblon, E3, ligase, ligand, 3, TCE35031, Tools, for, PROTAC, R&D, Tools, for, PROTAC, R&D, Tocris Bioscience

Citations for TC E3 5031

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