You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Phenyl-glutarimide 4'-oxyacetic acid
Phenyl-glutarimide 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC® Degrader development. The compound can be used to develop PG-PROTACs that exhibit improved stability to hydrolysis and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
This product is provided for use in onward chemistry. Suitable solvents can be used.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Min et al (2021) Phenyl-glutarimides: alternative cereblon binders for the design of PROTACs. Angew.Chem.Int.Ed. 60 26663 PMID: 34614283
If you know of a relevant reference for Phenyl-glutarimide 4'-oxyacetic acid, please let us know.
Keywords: Phenyl-glutarimide 4'-oxyacetic acid, Phenyl-glutarimide 4'-oxyacetic acid supplier, carboxylic, acid-functionalized, cereblon, ligand, phenyl-glutarimide, PROTAC, Degraders, building, blocks, targeted, protein, degradation, TPD, PG-PROTAC, pgprotac, protac-pg, Functionalized, E3, Ligase, Ligands, 7670, Tocris Bioscience
Citations for Phenyl-glutarimide 4'-oxyacetic acid
Citations are publications that use Tocris products.
Currently there are no citations for Phenyl-glutarimide 4'-oxyacetic acid. Do you know of a great paper that uses Phenyl-glutarimide 4'-oxyacetic acid from Tocris? Please let us know.
Reviews for Phenyl-glutarimide 4'-oxyacetic acid
There are currently no reviews for this product. Be the first to review Phenyl-glutarimide 4'-oxyacetic acid and earn rewards!
Have you used Phenyl-glutarimide 4'-oxyacetic acid?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia