Thalidomide, propargyl

Pricing Availability   Qty
Cat.No. 6685 - Thalidomide, propargyl | C16H12N2O5 | CAS No. 2098487-39-7
Description: Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs
Chemical Name: 2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Click-activated Thalidomide (Cat.No. 0652); can be used as a precursor to a PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Require a different derivative? Get in touch.

Usage guidelines:

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data

M. Wt 312.28
Formula C16H12N2O5
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2098487-39-7
PubChem ID 132118478
InChI Key NOGQTNDSZFYNTM-UHFFFAOYSA-N
Smiles O=C1N(C(C2=C(C=CC=C12)OCC#C)=O)C3CCC(NC3=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Wurz et al (2018) A "click chemistry platform" for the rapid rynthesis of bispecific molecules for inducing protein degradation. J.Med.Chem. 61 453 PMID: 28378579


If you know of a relevant reference for Thalidomide, propargyl, please let us know.

Keywords: Thalidomide, propargyl, Thalidomide, propargyl supplier, PROTACs, click-activated, thalidomide, E3, ligase, ligands, cereblon, PROTAC, Toolbox, targeted, protein, degradation, development, Functionalized, Ligase, Ligands, 6685, Tocris Bioscience

Citations for Thalidomide, propargyl

Citations are publications that use Tocris products.

Currently there are no citations for Thalidomide, propargyl. Do you know of a great paper that uses Thalidomide, propargyl from Tocris? Please let us know.

Reviews for Thalidomide, propargyl

There are currently no reviews for this product. Be the first to review Thalidomide, propargyl and earn rewards!

Have you used Thalidomide, propargyl?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia