Click-activated Thalidomide (Cat.No. 0652); can be used as a precursor to PROTACs that hijack cereblon as the E3 ubiquitin ligase component. Supplied with an alkyne functional handle at a position known not to significantly affect binding to cereblon, for ready click conjugation to a linker/target protein ligand.
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|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 312.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.2 mL||16.01 mL||32.02 mL|
|5 mM||0.64 mL||3.2 mL||6.4 mL|
|10 mM||0.32 mL||1.6 mL||3.2 mL|
|50 mM||0.06 mL||0.32 mL||0.64 mL|
References are publications that support the biological activity of the product.
Wurz et al (2018) A "click chemistry platform" for the rapid rynthesis of bispecific molecules for inducing protein degradation. J.Med.Chem. 61 453 PMID: 28378579
If you know of a relevant reference for Thalidomide, propargyl, please let us know.
Keywords: Thalidomide, propargyl, Thalidomide, propargyl supplier, PROTACs, click-activated, thalidomide, E3, ligase, ligands, cereblon, PROTAC, Toolbox, targeted, protein, degradation, development, Degrader, Building, Blocks, 6685, Tocris Bioscience
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