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PD 4'-oxyacetic acid
Biological Activity for PD 4'-oxyacetic acid
PD 4'-oxyacetic is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC® Degrader development. The compound can be used to develop PD-PROTACs that exhibit improved stability and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for PD 4'-oxyacetic acid
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for PD 4'-oxyacetic acid
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PD 4'-oxyacetic acid
References for PD 4'-oxyacetic acid
References are publications that support the biological activity of the product.
Jarusiewicz et al (2023) Phenyl dihydrouracil: an alternative cereblon binder for PROTAC design. ACS Med.Chem.Lett.
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Citations for PD 4'-oxyacetic acid
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Literature in this Area
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Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia