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UNC 1215, acid is a functionalized L3MBTL3 ligand for PROTAC® research and development. L3MBTL3-recruiting PROTACs induce nuclear-specific protein degradation of target proteins, such as FKBP12(F36V) and BRD2. UNC 1215, acid contains a carboxylic acid handle ready for conjugation to a target protein ligand.
Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
This product is provided for use in onward chemistry. Suitable solvents can be used.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Nalawansha et al (2022) Hijacking methyl reader proteins for nuclear-specific protein degradation. J.Am.Chem.Soc. 144 5594 PMID: 35311258
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Keywords: UNC 1215, acid, UNC 1215, acid supplier, UNC1215, acid, L3MBTL3, functionalized, ligand, ligands, targeted, protein, degradation, building, blocks, components, TPD, degraders, PROTACs, Functionalized, E3, Ligase, Ligands, 7759, Tocris Bioscience
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia