cis VH 032, amine dihydrochloride

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Cat.No. 6969 - cis VH 032, amine dihydrochloride | C22H30N4O3S.2HCl | CAS No. 2376990-32-6
Description: Negative control for VH 032, amine (Cat. No. 6462)
Chemical Name: (2S,4S)-1-[(2S)-2-Amino-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Negative control for the functionalized VHL ligand VH 032, amine (Cat. No. 6462).

Technical Data

M. Wt 503.48
Formula C22H30N4O3S.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 2376990-32-6
Smiles CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@@H](CN3C([C@H](C(C)(C)C)N)=O)O)=O)SC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.17 50
water 10.07 20

Preparing Stock Solutions

The following data is based on the product molecular weight 503.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.97 mL 19.86 mL 39.72 mL
2.5 mM 0.79 mL 3.97 mL 7.94 mL
5 mM 0.4 mL 1.99 mL 3.97 mL
25 mM 0.08 mL 0.4 mL 0.79 mL

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References are publications that support the biological activity of the product.

If you know of a relevant reference for cis VH 032, amine dihydrochloride, please let us know.

Keywords: cis VH 032, amine dihydrochloride, cis VH 032, amine dihydrochloride supplier, VH032, amine, 2HCl, protein, degrader, 1, VHL, VL, 269, PROTACs, E3, ligase, ligands, negative, control, 2115897-23-7, 1797406-78-0, Functionalized, Ligase, Ligands, 6969, Tocris Bioscience

Citations for cis VH 032, amine dihydrochloride

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Literature in this Area

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Targeted Protein Degradation

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia