CST 530, Phenol

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Description: Functionalized IAP ligand for PROTACs®
Chemical Name: tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((2S,4S)-4-(3-hydroxyphenoxy)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for CST 530, Phenol

CST 530, Phenol is a functionalized IAP (XIAP and cIAP) ligand for PROTAC® research and development. Supplied with a phenol functional handle for ready conjugation to a linker/target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for CST 530, Phenol

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for CST 530, Phenol

M. Wt 676.86
Formula C38H52N4O7
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2241489-43-8
PubChem ID 138911358
InChI Key ZAGJVXJUYODMFQ-QEXUPYAZSA-N
Smiles CC(C)(C)OC(N(C)[C@@H](C)C(N[C@@H](C1CCCCC1)C(N2[C@@H](C[C@@H](C2)OC3=CC(O)=CC=C3)C(N[C@H]4C5=CC=CC=C5CCC4)=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for CST 530, Phenol

References for CST 530, Phenol

References are publications that support the biological activity of the product.

Ng et al (2023) Heterobifunctional ligase recruiters enable pan-degradation of inhibitor of apoptosis proteins. J.Med.Chem. 66 4703 PMID: 36996313


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Keywords: CST 530, Phenol, CST 530, Phenol supplier, CST530, phenol, degraders, degradation, targeted, protein, degrader, E3, ligase, protac, cIAP, cIAP1, IAP2, CRBN, cereblon, Functionalized, Ligase, Ligands, 8066, Tocris Bioscience

Citations for CST 530, Phenol

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Literature in this Area

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia