You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
A 410099.1, amine
Biological Activity for A 410099.1, amine
A 410099.1, amine is a functionalized IAP ligand for PROTAC® research and development. Boc protected A 410099.1 (Cat.No. 6470). Supplied with an amine functional handle for ready conjugation to a linker/target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for A 410099.1, amine
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for A 410099.1, amine
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for A 410099.1, amine
References for A 410099.1, amine
References are publications that support the biological activity of the product.
Tinworth et al (2019) PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding. ACS Chem.Biol. 14 342 PMID: 30807093
If you know of a relevant reference for A 410099.1, amine, please let us know.
Keywords: A 410099.1, amine, A 410099.1, amine supplier, A410099.1, amine, functionalized, boc, protected, E3, ligase, ligands, targeted, protein, degradation, building, blocks, components, TPD, degraders, PROTACs, IAP, inhibitor, of, apoptosis, Functionalized, Ligase, Ligands, 6471, Tocris Bioscience
Citations for A 410099.1, amine
Citations are publications that use Tocris products.
Currently there are no citations for A 410099.1, amine. Do you know of a great paper that uses A 410099.1, amine from Tocris? Please let us know.
Reviews for A 410099.1, amine
There are currently no reviews for this product. Be the first to review A 410099.1, amine and earn rewards!
Have you used A 410099.1, amine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia