N-methylated pomalidomide

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Description: Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control
Chemical Name: 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for N-methylated pomalidomide

N-methylated pomalidomide is a functionalized cereblon ligand for PROTAC® research and development. Can be used to generate negative controls for Pomalidomide (Cat. No. 6302)-based Degraders. Does not bind to cereblon. Part of a range of functionalized tool molecules for PROTAC R&D. Can also be used as a Pomalidomide negative control.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for N-methylated pomalidomide

M. Wt 287.27
Formula C14H13N3O4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1352827-50-9
PubChem ID 58572149
Smiles O=C1C=2C=CC=C(N)C2C(=O)N1C3C(=O)N(C(=O)CC3)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for N-methylated pomalidomide

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 28.73 100

Preparing Stock Solutions for N-methylated pomalidomide

The following data is based on the product molecular weight 287.27. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.48 mL 17.41 mL 34.81 mL
5 mM 0.7 mL 3.48 mL 6.96 mL
10 mM 0.35 mL 1.74 mL 3.48 mL
50 mM 0.07 mL 0.35 mL 0.7 mL

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Product Datasheets for N-methylated pomalidomide

References for N-methylated pomalidomide

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Keywords: N-methylated pomalidomide, N-methylated pomalidomide supplier, protacs, negative, control, proteolysis, targeting, chimera, cereblon, E3, CRBN, 1352827-50-9, ubiquitin, ligase, Functionalized, Ligase, Ligands, Ubiquitin, Ligases, 7716, Tocris Bioscience

Citations for N-methylated pomalidomide

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Literature in this Area

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia