You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
LCL 161, phenol
Biological Activity for LCL 161, phenol
LCL 161, phenol is a functionalized IAP (XIAP and cIAP) ligand for PROTAC® research and development. Boc protected LCL 161. Supplied with a phenol functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC50 values of 7.5, 18.2 and 25.3 nM for cIAP1, XIAP and cIAP2 proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for LCL 161, phenol
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for LCL 161, phenol
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for LCL 161, phenol
References are publications that support the biological activity of the product.
Ohoka et al (2017) In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). J.Biol.Chem. 292 4556 PMID: 28154167
Shimokawa et al (2017) Targeting the allosteric site of oncoprotein BCR-ABL as an alternative strategy for effective target protein degradation. ACS Med.Chem.Lett. 8 1042 PMID: 29057048
Schwalm et al (2022) A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins. Front.Cell.Dev.Biol. 10 886537 PMID: 35721509
If you know of a relevant reference for LCL 161, phenol, please let us know.
Keywords: LCL 161, phenol, LCL 161, phenol supplier, LCL161, functionalized, boc, protected, E3, ligase, ligands, targeted, protein, degradation, building, blocks, components, TPD, degraders, PROTACs, IAP, inhibitor, of, apoptosis, XIAP, cIAP, BIRC1, BIRC2, BIRC3, Functionalized, Ligase, Ligands, 7178, Tocris Bioscience
Citations for LCL 161, phenol
Citations are publications that use Tocris products.
Currently there are no citations for LCL 161, phenol. Do you know of a great paper that uses LCL 161, phenol from Tocris? Please let us know.
Reviews for LCL 161, phenol
There are currently no reviews for this product. Be the first to review LCL 161, phenol and earn rewards!
Have you used LCL 161, phenol?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia