Benzamil

Pricing Availability Delivery Time Qty
Cat.No. 3380 - Benzamil | C13H14ClN7O.HCl | CAS No. 161804-20-2
Description: NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative
Chemical Name: N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 μM for inhibition of Ca2+-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).

Compound Libraries

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Technical Data

M. Wt 356.21
Formula C13H14ClN7O.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 161804-20-2
PubChem ID 5702295
InChI Key ZNWMRWWNJBXNKJ-UHFFFAOYSA-N
Smiles NC1=C(Cl)N=C(C(NC(NCC2=CC=CC=C2)=N)=O)C(N)=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.62 100
water 3.56 10

Preparing Stock Solutions

The following data is based on the product molecular weight 356.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.81 mL 14.04 mL 28.07 mL
5 mM 0.56 mL 2.81 mL 5.61 mL
10 mM 0.28 mL 1.4 mL 2.81 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. Mol.Pharmacol. 72 1576 PMID: 17804601

Fischer et al (2002) Characterization of a Na+-Ca2+ exchanger in podocytes. Nephrol.Dial.Transplant. 17 1742 PMID: 12270979

Page et al (2007) Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain 133 150 PMID: 17467171


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View all Na+/Ca2+ Exchanger Inhibitors

Keywords: Benzamil, supplier, non-selective, Deg, ENaC, family, NCX, sodium, calcium, Na+/Ca2+, exchanger, inhibitors, inhibits, amiloride, derivative, TRPP3, channel, blocker, Na+/Ca2+, Exchanger, Epithelial, Sodium, Channels, TRPP, Na+/Ca2+, Exchanger, Tocris Bioscience

Citations for Benzamil

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Cardiovascular

Cardiovascular Research Product Guide

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