YM 244769

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Cat.No. 4544 - YM 244769 | C26H22FN3O3.2HCl | CAS No. 837424-39-2
Description: Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective
Chemical Name: N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

Compound Libraries

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Technical Data

M. Wt 516.39
Formula C26H22FN3O3.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 837424-39-2
PubChem ID 90488952
InChI Key OCKIUNLKEPKCRE-UHFFFAOYSA-N
Smiles NC1=CC=CC(CNC(C2=CN=C(OC3=CC=C(OCC4=CC=CC(F)=C4)C=C3)C=C2)=O)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 51.64 100

Preparing Stock Solutions

The following data is based on the product molecular weight 516.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.68 mL 19.37 mL
5 mM 0.39 mL 1.94 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Iwamoto et al (2007) Na+/Ca2+ exchange inhibitors: a new class of calcium regulators. Cardiovasc.Hematol.Disord.Drug Targets 7 188 PMID: 17896959

Iwamoto and Kita (2006) YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol.Pharmacol. 70 2075 PMID: 16973719


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Keywords: YM 244769, supplier, YM244769, anti-ischemic, anti-ischaemic, hypoxia/reoxygenation, injury, neuroprotective, Na+, Ca2+, exchangers, NCX, NCX3, NCX2, NCX1, inhibitors, inhibits, reverse, mode, selective, Na+/Ca2+, Exchanger, Tocris Bioscience

Citations for YM 244769

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Cardiovascular

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