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Submit ReviewYM 244769
Description: Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective
Chemical Name: N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
Purity: ≥99% (HPLC)
Biological Activity for YM 244769
YM 244769 is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.
Compound Libraries for YM 244769
YM 244769 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for YM 244769
| M. Wt | 516.39 |
| Formula | C26H22FN3O3.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1780390-65-9 |
| PubChem ID | 90488952 |
| InChI Key | OCKIUNLKEPKCRE-UHFFFAOYSA-N |
| Smiles | NC1=CC=CC(CNC(C2=CN=C(OC3=CC=C(OCC4=CC=CC(F)=C4)C=C3)C=C2)=O)=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for YM 244769
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.64 | 100 |
Preparing Stock Solutions for YM 244769
The following data is based on the product molecular weight 516.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.94 mL | 9.68 mL | 19.37 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.87 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.94 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
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Product Datasheets for YM 244769
References for YM 244769
References are publications that support the biological activity of the product.
Iwamoto et al (2007) Na+/Ca2+ exchange inhibitors: a new class of calcium regulators. Cardiovasc.Hematol.Disord.Drug Targets 7 188 PMID: 17896959
Iwamoto and Kita (2006) YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol.Pharmacol. 70 2075 PMID: 16973719
If you know of a relevant reference for YM 244769, please let us know.
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Keywords: YM 244769, YM 244769 supplier, YM244769, anti-ischemic, anti-ischaemic, hypoxia/reoxygenation, injury, neuroprotective, Na+, Ca2+, exchangers, NCX, NCX3, NCX2, NCX1, inhibitors, inhibits, reverse, mode, selective, Na+/Ca2+, Exchanger, 4544, Tocris Bioscience
5 Citations for YM 244769
Citations are publications that use Tocris products. Selected citations for YM 244769 include:
Xiaoli et al (2022) Suppressing Effect of Na+/Ca2+ Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells. Int J Mol Sci 23 PMID: 35055084
Hajime et al (2022) Activation of Glutamate Transport Increases Arteriole Diameter in v ivo: Implications for Neurovascular Coupling. Front Cell Neurosci 16 831061 PMID: 35308116
Yan et al (2019) Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death. Br J Pharmacol 176 2691-2707 PMID: 31034096
O'Donnell et al (2016) Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. J Neurosci 36 7109 PMID: 27383588
Mohadeseh et al (2021) The cellular prion protein interacts with and promotes the activity of Na,K-ATPases. PLoS One 16 e0258682 PMID: 34847154
Do you know of a great paper that uses YM 244769 from Tocris? Please let us know.
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