YM 244769

Pricing Availability   Qty
Description: Na+/Ca2+ exchange inhibitor (reverse mode); neuroprotective
Chemical Name: N-[(3-Aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-3-pyridinecarboxamide dihydrochloride
Purity: ≥99% (HPLC)
Citations (5)

Biological Activity for YM 244769

YM 244769 is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX). Potently inhibits Na+-dependent 45Ca2+ uptake (IC50 values are 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively). Displays selectivity for NCX over other Na+ and Ca2+ transporters. Protects against hypoxia/reoxygenation-induced cell damage in neuronal SH-SY5Y cells expressing NCX1 and NCX3.

Compound Libraries for YM 244769

YM 244769 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YM 244769

M. Wt 516.39
Formula C26H22FN3O3.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1780390-65-9
PubChem ID 90488952
Smiles NC1=CC=CC(CNC(C2=CN=C(OC3=CC=C(OCC4=CC=CC(F)=C4)C=C3)C=C2)=O)=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for YM 244769

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.64 100

Preparing Stock Solutions for YM 244769

The following data is based on the product molecular weight 516.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.68 mL 19.37 mL
5 mM 0.39 mL 1.94 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for YM 244769

References are publications that support the biological activity of the product.

Iwamoto et al (2007) Na+/Ca2+ exchange inhibitors: a new class of calcium regulators. Cardiovasc.Hematol.Disord.Drug Targets 7 188 PMID: 17896959

Iwamoto and Kita (2006) YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol.Pharmacol. 70 2075 PMID: 16973719

If you know of a relevant reference for YM 244769, please let us know.

View Related Products by Product Action

View all Na+/Ca2+ Exchanger Inhibitors

Keywords: YM 244769, YM 244769 supplier, YM244769, anti-ischemic, anti-ischaemic, hypoxia/reoxygenation, injury, neuroprotective, Na+, Ca2+, exchangers, NCX, NCX3, NCX2, NCX1, inhibitors, inhibits, reverse, mode, selective, Na+/Ca2+, Exchanger, 4544, Tocris Bioscience

5 Citations for YM 244769

Citations are publications that use Tocris products. Selected citations for YM 244769 include:

O'Donnell et al (2016) Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes. J Neurosci 36 7109 PMID: 27383588

Mohadeseh et al (2021) The cellular prion protein interacts with and promotes the activity of Na,K-ATPases. PLoS One 16 e0258682 PMID: 34847154

Xiaoli et al (2022) Suppressing Effect of Na+/Ca2+ Exchanger (NCX) Inhibitors on the Growth of Melanoma Cells. Int J Mol Sci 23 PMID: 35055084

Hajime et al (2022) Activation of Glutamate Transport Increases Arteriole Diameter in v ivo: Implications for Neurovascular Coupling. Front Cell Neurosci 16 831061 PMID: 35308116

Do you know of a great paper that uses YM 244769 from Tocris? Please let us know.

Reviews for YM 244769

There are currently no reviews for this product. Be the first to review YM 244769 and earn rewards!

Have you used YM 244769?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review