SN-6

Pricing Availability Delivery Time Qty
Cat.No. 2184 - SN-6 | C20H22N2O5S | CAS No. 415697-08-4
Description: Selective Na+/Ca2+ exchange inhibitor (reverse mode)
Chemical Name: 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Selective Na+/Ca2+-exchange (NCX) inhibitor; displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943 (Cat. No. 1244). Anti-ischemic; potently protects against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM).

Compound Libraries

SN-6 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 402.16
Formula C20H22N2O5S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 415697-08-4
PubChem ID 10222761
InChI Key ZVYIJXLMBWCGHP-UHFFFAOYSA-N
Smiles CCOC(=O)C1CSC(CC2=CC=C(OCC3=CC=C(C=C3)[N+]([O-])=O)C=C2)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.22 100

Preparing Stock Solutions

The following data is based on the product molecular weight 402.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.43 mL 24.87 mL
5 mM 0.5 mL 2.49 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Iwamoto et al (2004) The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol.Pharmacol. 66 45 PMID: 15213295

Iwamoto (2004) Forefront of Na+/Ca2+ exchanger studies: molecular pharmacology of N+/Ca2+ exchange inhibitors. J.Pharmacol.Sci. 96 27 PMID: 15359084


If you know of a relevant reference for SN-6, please let us know.

View Related Products by Product Action

View all Na+/Ca2+ Exchanger Inhibitors

Keywords: SN-6, supplier, Selective, Na+/Ca2+, exchange, inhibitors, inhibits, reverse, mode, Sodium, Calcium, Exchanger, Ion, Transporters, Pumps, Ca2+, Signaling, Signalling, NCX1, Na+/Ca2+, Exchanger, Na+/Ca2+, Exchanger, Tocris Bioscience

5 Citations for SN-6

Citations are publications that use Tocris products. Selected citations for SN-6 include:

Wang et al (2015) Conditional knockout of smooth muscle sodium calcium exchanger type-1 lowers blood pressure and attenuates Angiotensin II-salt hypertension. Sci Signal 3 PMID: 25626872

Ciapa and Philippe (2013) Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities. PLoS One 8 e66113 PMID: 23785474

Wang et al (2012) Astrocytes modulate neural network activity by Ca2+-dependent uptake of extracellular K+. Cell Cycle 5 ra26 PMID: 22472648

Fu and Pol (2010) Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism. J Neurosci 30 10205 PMID: 20668204

Barrientos et al (2009) The Na+/Ca2+ exchange inhibitor 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate (KB-R7943) also blocks ryanodine receptors type 1 (RyR1) and type 2 (RyR2) channels. Mol Pharmacol 76 560 PMID: 19509218


Do you know of a great paper that uses SN-6 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure

Pathways for SN-6

Protocols

TODO: Add Protocols