Selective antagonist of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in DMSO|
Preparing Stock Solutions
The following data is based on the product molecular weight 324.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.08 mL||15.42 mL||30.84 mL|
|5 mM||0.62 mL||3.08 mL||6.17 mL|
|10 mM||0.31 mL||1.54 mL||3.08 mL|
|50 mM||0.06 mL||0.31 mL||0.62 mL|
References are publications that support the products' biological activity.
Baron and Thayer (1997) CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons. Eur.J.Pharmacol. 340 295 PMID: 9537826
Cox et al (1993) Selectivity of inhibition of Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J.Cardiovasc.Pharmacol. 21 595 PMID: 7681905
Cox and Matlib (1993) Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchange. TiPS 14 408 PMID: 8296399
White and Reynolds (1997) Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones. J.Physiol. 498 31 PMID: 9023766
If you know of a relevant reference for CGP 37157, please let us know.
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Keywords: CGP 37157, supplier, Antagonists, mitochondrial, Na+/Ca2+, Exchanger, Ca2+, Signaling, Signalling, Calcium, Sodium, Ion, Transporters, Pumps, CGP37157, NCX, Na+/Ca2+, Exchanger, Na+/Ca2+, Exchanger, Tocris Bioscience
9 Citations for CGP 37157
Citations are publications that use Tocris products. Selected citations for CGP 37157 include:
Pandit et al (2012) Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production. Am J Physiol Renal Physiol 302 F1325 PMID: 22357920
Schild et al (2003) Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration. Am J Physiol Heart Circ Physiol 278 25454 PMID: 12702720
Lin et al (2015) Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Elife 16 5555 PMID: 25768340
Yang et al (2015) Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function. J Biol Chem 4 PMID: 25974216
Pecze et al (2015) Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. World J Gastroenterol 290 28214 PMID: 26396196
Blomeyer et al (2013) Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release. J Bioenerg Biomembr 45 189 PMID: 23225099
Zhdanov et al (2011) Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria. Cell Mol Life Sci 68 903 PMID: 20820851
Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395 PMID: 21966518
Kim et al (2006) Involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity. J Biol Chem 12 796 PMID: 16521198
Do you know of a great paper that uses CGP 37157 from Tocris? If so please let us know.
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Literature in this Area
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