CGP 37157

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Cat.No. 1114 - CGP 37157 | C15H11Cl2NOS | CAS No. 75450-34-9
Description: Antagonist of mitochondrial Na+/Ca2+ exchange
Chemical Name: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations (11)
Reviews
Literature

Biological Activity

Selective antagonist of the mitochondrial Na+-Ca2+ exchanger (IC50 = 0.4 μM).

Compound Libraries

CGP 37157 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 324.22
Formula C15H11Cl2NOS
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 75450-34-9
PubChem ID 2688
InChI Key KQEPIRKXSUIUTH-UHFFFAOYSA-N
Smiles ClC1=CC=C2NC(=O)CSC(C3=CC=CC=C3Cl)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Baron and Thayer (1997) CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons. Eur.J.Pharmacol. 340 295 PMID: 9537826

Cox et al (1993) Selectivity of inhibition of Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157. J.Cardiovasc.Pharmacol. 21 595 PMID: 7681905

Cox and Matlib (1993) Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchange. TiPS 14 408 PMID: 8296399

White and Reynolds (1997) Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones. J.Physiol. 498 31 PMID: 9023766


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Keywords: CGP 37157, CGP 37157 supplier, Antagonists, mitochondrial, Na+/Ca2+, Exchanger, Ca2+, Signaling, Signalling, Calcium, Sodium, Ion, Transporters, Pumps, CGP37157, NCX, 1114, Tocris Bioscience

11 Citations for CGP 37157

Citations are publications that use Tocris products. Selected citations for CGP 37157 include:

Schild et al (2003) Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration. Am J Physiol Heart Circ Physiol 278 25454 PMID: 12702720

Zhdanov et al (2011) Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria. Cell Mol Life Sci 68 903 PMID: 20820851

Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395 PMID: 21966518

Lee et al (2007) Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses. J Neurosci 27 13603 PMID: 18077672

Kim et al (2006) Involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity. J Biol Chem 12 796 PMID: 16521198

Lin et al (2015) Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals. Elife 16 5555 PMID: 25768340

Yang et al (2015) Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function. J Biol Chem 4 PMID: 25974216

Pecze et al (2015) Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS. World J Gastroenterol 290 28214 PMID: 26396196

Pandit et al (2012) Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production. Am J Physiol Renal Physiol 302 F1325 PMID: 22357920

Blomeyer et al (2013) Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release. J Bioenerg Biomembr 45 189 PMID: 23225099

Nikolaeva et al (2005) Na+-dependent sources of intra-axonal Ca2+ release in rat optic nerve during in vitro chemical ischemia. J Neurosci 25 9960 PMID: 16251444


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