Calcium channel blocker. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; opens mitochondrial KATP channels. Antiarrhythmic and antihypertensive; acts as a calcium sensitizer.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 403. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.48 mL||12.41 mL||24.81 mL|
|5 mM||0.5 mL||2.48 mL||4.96 mL|
|10 mM||0.25 mL||1.24 mL||2.48 mL|
|50 mM||0.05 mL||0.25 mL||0.5 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Yatani et al (1986) Bepridil block of cardiac calcium and sodium channels. J.Pharmacol.Exp.Ther. 237 9 PMID: 2420970
Wantanabe and Kimura (2001) Blocking effect of bepridil on Na+/ Ca2+ exchange current in gunea pig cardiac ventricular myocytes. Jpn.J.Pharmacol. 85 370 PMID: 11388640
Sato et al (2006) Bepridil, an antiarrythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J.Pharmacol.Exp.Ther. 316 182 PMID: 16174795
Gill et al (1992) Pharmacology of bepridil. Am.J.Cardiol. 69 11D PMID: 1372785
If you know of a relevant reference for Bepridil hydrochloride, please let us know.
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Keywords: Bepridil hydrochloride, supplier, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, NCX, sodium-calcium, exchangers, KATP, antiarrhythmics, Voltage-gated, Calcium, Channels, Na+/Ca2+, Exchanger, Voltage-gated, Calcium, Channels, Tocris Bioscience
1 Citation for Bepridil hydrochloride
Citations are publications that use Tocris products. Selected citations for Bepridil hydrochloride include:
Ciapa and Philippe (2013) Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities. PLoS One 8 e66113 PMID: 23785474
Do you know of a great paper that uses Bepridil hydrochloride from Tocris? If so please let us know.
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