Bepridil hydrochloride

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Cat.No. 4117 - Bepridil hydrochloride | C24H34N2O.HCl | CAS No. 68099-86-5
Description: Non-selective Ca2+ channel blocker; also NCX inhibitor
Chemical Name: N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (1)

Biological Activity

Calcium channel blocker. Also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels; opens mitochondrial KATP channels. Antiarrhythmic and antihypertensive; acts as a calcium sensitizer.

Compound Libraries

Bepridil hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 403
Formula C24H34N2O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 68099-86-5
PubChem ID 50088
InChI Key JXBBWYGMTNAYNM-UHFFFAOYSA-N
Smiles CC(C)COCC(N3CCCC3)CN(C2=CC=CC=C2)CC1=CC=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 403. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.41 mL 24.81 mL
5 mM 0.5 mL 2.48 mL 4.96 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Yatani et al (1986) Bepridil block of cardiac calcium and sodium channels. J.Pharmacol.Exp.Ther. 237 9 PMID: 2420970

Wantanabe and Kimura (2001) Blocking effect of bepridil on Na+/ Ca2+ exchange current in gunea pig cardiac ventricular myocytes. Jpn.J.Pharmacol. 85 370 PMID: 11388640

Sato et al (2006) Bepridil, an antiarrythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J.Pharmacol.Exp.Ther. 316 182 PMID: 16174795

Gill et al (1992) Pharmacology of bepridil. Am.J.Cardiol. 69 11D PMID: 1372785


If you know of a relevant reference for Bepridil hydrochloride, please let us know.

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View all Non-selective Cav Channel Blockers

Keywords: Bepridil hydrochloride, Bepridil hydrochloride supplier, calcium, channels, Ca2+, blockers, inhibitors, inhibits, selective, voltage-gated, voltage-dependent, CaV, NCX, sodium-calcium, exchangers, KATP, antiarrhythmics, Non-selective, Cav, Channels, Na+/Ca2+, Exchanger, 4117, Tocris Bioscience

1 Citation for Bepridil hydrochloride

Citations are publications that use Tocris products. Selected citations for Bepridil hydrochloride include:

Ciapa and Philippe (2013) Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities. PLoS One 8 e66113 PMID: 23785474


Do you know of a great paper that uses Bepridil hydrochloride from Tocris? Please let us know.

Reviews for Bepridil hydrochloride

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Bepridil used on Cav1.2 channels.
By Anonymous on 02/04/2019
Species: Human

Product used on Cav1.2 channels to understand it blocking mechanism on the specific channel.

review image

Literature in this Area

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