Sal 003

Pricing Availability Delivery Time Qty
Cat.No. 3657 - Sal 003 | C18H15Cl4N3OS | CAS No. 1164470-53-4
Description: Cell-permeable inhibitor of eIF2α dephosphorylation
Chemical Name: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

Cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.

Compound Libraries

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Technical Data

M. Wt 463.21
Formula C18H15Cl4N3OS
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1164470-53-4
PubChem ID 5717737
InChI Key TVNBASWNLOIQML-IZZDOVSWSA-N
Smiles S=C(NC(NC(/C=C/C2=CC=CC=C2)=O)C(Cl)(Cl)Cl)NC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 463.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.59 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Raven et al (2008) PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation. J.Biol.Chem. 283 3097 PMID: 18063576

Baltiz et al (2007) The eIF2α kinases PERK and PKR activate glucogen synthase kinase 3 to promote the proteasomal degradation of p53. J.Biol.Chem. 282 31675 PMID: 17785458

Costa-Mattioli et al (2007) eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell 129 195 PMID: 17418795


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Keywords: Sal 003, Sal 003 supplier, Cell, permeable, inhibitors, cellular, phosphatases, complexes, dephosphorylates, eukaryotic, translation, initiation, factor, 2, subunit, α, eIF2, eIF2a, eIF2alpha, Sal003, inhibits, Protein, Ser/Thr, Phosphatases, 3657, Tocris Bioscience

2 Citations for Sal 003

Citations are publications that use Tocris products. Selected citations for Sal 003 include:

Krokowski (2017) GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells. Cell Rep 21 2895 PMID: 29212034

Devi and Ohno (2010) Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice. PLoS One 5 e12974 PMID: 20886088


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