Sal 003

Pricing Availability   Qty
Description: Cell-permeable inhibitor of eIF2α dephosphorylation
Chemical Name: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Purity: ≥99% (HPLC)
Citations (5)

Biological Activity for Sal 003

Sal 003 is a cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.

Compound Libraries for Sal 003

Sal 003 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Sal 003

M. Wt 463.21
Formula C18H15Cl4N3OS
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1164470-53-4
PubChem ID 5717737
Smiles S=C(NC(NC(/C=C/C2=CC=CC=C2)=O)C(Cl)(Cl)Cl)NC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sal 003

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.32 100

Preparing Stock Solutions for Sal 003

The following data is based on the product molecular weight 463.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.59 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Sal 003

References are publications that support the biological activity of the product.

Raven et al (2008) PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation. J.Biol.Chem. 283 3097 PMID: 18063576

Baltiz et al (2007) The eIF2α kinases PERK and PKR activate glucogen synthase kinase 3 to promote the proteasomal degradation of p53. J.Biol.Chem. 282 31675 PMID: 17785458

Costa-Mattioli et al (2007) eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell 129 195 PMID: 17418795

If you know of a relevant reference for Sal 003, please let us know.

View Related Products by Product Action

View all Protein Ser/Thr Phosphatases Inhibitors

Keywords: Sal 003, Sal 003 supplier, Cell, permeable, inhibitors, cellular, phosphatases, complexes, dephosphorylates, eukaryotic, translation, initiation, factor, 2, subunit, α, eIF2, eIF2a, eIF2alpha, Sal003, inhibits, Protein, Ser/Thr, Phosphatases, Protein-synthesizing, GTPases, 3657, Tocris Bioscience

5 Citations for Sal 003

Citations are publications that use Tocris products. Selected citations for Sal 003 include:

Jing et al (2022) Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR. Cell Rep 40 111092 PMID: 35858571

Albert S et al (2022) Integrated Stress Response Regulation of Corneal Epithelial Cell Motility and Cytokine Production. Invest Ophthalmol Vis Sci 63 1 PMID: 35802384

Jing et al (2021) Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress. Mol Cell 81 4191-4208.e8 PMID: 34686314

Krokowski (2017) GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells. Cell Rep 21 2895 PMID: 29212034

Do you know of a great paper that uses Sal 003 from Tocris? Please let us know.

Reviews for Sal 003

There are currently no reviews for this product. Be the first to review Sal 003 and earn rewards!

Have you used Sal 003?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review