Sal 003

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Cat.No. 3657 - Sal 003 | C18H15Cl4N3OS | CAS No. 1164470-53-4
Description: Cell-permeable inhibitor of eIF2α dephosphorylation
Chemical Name: 3--Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide
Purity: ≥99% (HPLC)
Citations (1)

Biological Activity

Cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.

Compound Libraries

Sal 003 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 463.21
Formula C18H15Cl4N3OS
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1164470-53-4
PubChem ID 5717737
Smiles S=C(NC(NC(/C=C/C2=CC=CC=C2)=O)C(Cl)(Cl)Cl)NC1=CC=C(Cl)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.32 100

Preparing Stock Solutions

The following data is based on the product molecular weight 463.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.59 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Raven et al (2008) PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation. J.Biol.Chem. 283 3097 PMID: 18063576

Baltiz et al (2007) The eIF2α kinases PERK and PKR activate glucogen synthase kinase 3 to promote the proteasomal degradation of p53. J.Biol.Chem. 282 31675 PMID: 17785458

Costa-Mattioli et al (2007) eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell 129 195 PMID: 17418795

If you know of a relevant reference for Sal 003, please let us know.

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View all Protein Ser/Thr Phosphatases Inhibitors

Keywords: Cell permeable inhibitors cellular phosphatases complexes dephosphorylates eukaryotic translation initiation factor 2 subunit α eIF2 eIF2a eIF2alpha Sal003 inhibits Protein Ser/Thr Phosphatases

1 Citation for Sal 003

Citations are publications that use Tocris products. Selected citations for Sal 003 include:

Devi and Ohno (2010) Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice. PLoS One 5 e12974 PMID: 20886088

Do you know of a great paper that uses Sal 003 from Tocris? If so please let us know.

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Pathways for Sal 003


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