Cell-permeable inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2α). Analog of salubrinal (Cat. No. 2347) with improved aqueous solubility. Shown to prevent the induction of hippocampal long-term potentiation (LTP) and memory formation (LTM) in mice.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 463.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.16 mL||10.79 mL||21.59 mL|
|5 mM||0.43 mL||2.16 mL||4.32 mL|
|10 mM||0.22 mL||1.08 mL||2.16 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Raven et al (2008) PKR and PKR-like endoplasmic reticulum kinase induce the protease-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation. J.Biol.Chem. 283 3097 PMID: 18063576
Baltiz et al (2007) The eIF2α kinases PERK and PKR activate glucogen synthase kinase 3 to promote the proteasomal degradation of p53. J.Biol.Chem. 282 31675 PMID: 17785458
Costa-Mattioli et al (2007) eIF2α phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell 129 195 PMID: 17418795
If you know of a relevant reference for Sal 003, please let us know.
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Keywords: Cell permeable inhibitors cellular phosphatases complexes dephosphorylates eukaryotic translation initiation factor 2 subunit α eIF2 eIF2a eIF2alpha Sal003 inhibits Protein Ser/Thr Phosphatases
1 Citation for Sal 003
Citations are publications that use Tocris products. Selected citations for Sal 003 include:
Devi and Ohno (2010) Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice. PLoS One 5 e12974 PMID: 20886088
Do you know of a great paper that uses Sal 003 from Tocris? If so please let us know.