Protein Ser/Thr Phosphatases

Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Data

Protein Ser/Thr Phosphatases Inhibitors

Cat. No. Product Name / Activity
1336 Calyculin A
Protein phosphatase 1 and 2A inhibitor
1101 Cyclosporin A
Calcineurin inhibitor
3631 FK 506
Potent calcineurin inhibitor; immunosuppressant
1840 Fostriecin sodium salt
Potent PP2A and PP4 inhibitor
5140 GSK 2830371
Potent and selective allosteric inhibitor of Wip1 phosphatase
2162 INCA-6
Inhibitor of calcineurin-substrate association
1136 Okadaic acid
Protein phosphatase 1 and 2A inhibitor
6760 Raphin 1
Inhibitor of the regulatory subunit PPP1R15B of protein phosphatase 1; orally bioavailable and brain penetrant
3657 Sal 003
Cell-permeable inhibitor of eIF2α dephosphorylation
2347 Salubrinal
Selective inhibitor of eIF2α dephosphorylation
2302 Sanguinarine chloride
Inhibitor of protein phosphatase 2C (PP2C)
5553 Sephin 1
Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1

Protein Ser/Thr Phosphatases Activators

Cat. No. Product Name / Activity
0744 Ceramide
Ser/Thr protein phosphatase activator

Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways.

There are two groups of serine/threonine phosphatases: phosphoprotein phosphatases (e.g. PP1, calcineurin), which are sensitive to okadaic acid; and metallo-phosphatases (e.g. PP2C), which require a divalent cation, commonly Mg2+, for catalytic activity. Dephosphorylation, depending on the residue that the phosphate group is removed from, can have a stimulatory or inhibitory effect on the target molecule. This makes protein Ser/Thr phosphatases essential for many signal transduction pathways, including histone dephosphorylation during epigenetic modification. Protein Ser/Thr phosphatase are regulated by their subcellular localization and by inhibitor proteins, which are subtype-specific.

External sources of pharmacological information for Protein Ser/Thr Phosphatases :

    Protein Ser/Thr Phosphatase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    PP1α Human PPP1CA NM_206873 P62136
    Mouse Ppp1ca NM_031868 P62137
    Rat Ppp1ca NM_031527 P62138
    PP1β Human PPP1CB NM_002709 P62140
    Mouse Ppp1cb NM_172707 P62141
    Rat Ppp1cb NM_013065 P62142
    PP1γ Human PPP1CC NM_002710 P36873
    Mouse Ppp1cc NM_013636 P63087
    Rat Ppp1cc NM_022498 P63088
    PP1 1A Human PPP1R1A NM_006741 Q13522
    Mouse Ppp1r1a NM_021391 Q9ERT9
    Rat Ppp1r1a NM_022676 P19103
    PP1 1B Human PPP1R1B NM_181505 Q9UD71
    Mouse Ppp1r1b NM_144828 Q60829
    Rat Ppp1r1b NM_138521 Q6J4I0
    PP1 1C Human PPP1R1C XM_087137 Q8WVI7
    Mouse Ppp1r1c NM_172420 Q8BKK4
    Rat Ppp1r1c NM_001109200 XP_575157
    PP1 2 Human PPP1R2 NM_006241 P41236
    Mouse Ppp1r2 NM_025800 Q9DCL8
    Rat Ppp1r2 NM_138823 P50411
    PP1 3A Human PPP1R3A NM_002711 Q16821
    Mouse Ppp1r3a NM_080464 Q99MR9
    Rat Ppp1r3a NM_001109222 XP_575392
    PP1 3B Human PPP1R3B NM_024607 Q86XI6
    Mouse Ppp1r3b NM_177741 Q8C767
    Rat Ppp1r3b NM_138912 Q6IN01
    PP1 3C Human PPP1R3C NM_005398 Q9UQK1
    Mouse Ppp1r3c NM_016854 Q7TMB3
    Rat Ppp1r3c NM_001012072 Q5U2R5
    PP1 3D Human PPP1R3D NM_006242 O95685
    Mouse Ppp1r3d NM_001085501 NP_001078970
    Rat Ppp1r3d NM_001109564 XP_001072850
    PP1 3E Human PPP1R3E XR_040049 Q9H7J1
    Mouse Ppp1r3e AK131886 Q8BRJ4
    Rat Ppp1r3e XM_001078311 P0C7L8
    PP1 3F Human PPP1R3F NM_033215 Q6ZSY5
    Mouse Ppp1r3f NM_138605 Q9JIG4
    PP1 7 Human PPP1R7 NM_002712 Q15435
    Mouse Ppp1r7 NM_023200 Q3UM45
    Rat Ppp1r7 NM_001009825 Q5HZV9
    PP1 8 Human PPP1R8 NM_014110 Q12972
    Mouse Ppp1r8 NM_146154 Q8R3G1
    Rat Ppp1r8 NM_001107911 XP_232739
    PP1 9A Human PPP1R9A NM_017650 Q9ULJ8
    Mouse Ppp1r9a NM_181595 NP_853626
    Rat Ppp1r9a NM_053473 O35867
    PP1 9B Human PPP1R9B NM_032595 Q96SB3
    Mouse Ppp1r9b NM_172261 Q6R891
    Rat Ppp1r9b NM_053474 O35274
    PP1 10 Human PPP1R10 NM_002714 Q96QC0
    Mouse Ppp1r10 NM_175934 Q80W00
    Rat Ppp1r10 NM_022951 O55000
    PP1 11 Human PPP1R11 NM_021959 O60927
    Mouse Ppp1r11 NM_029632 Q8K1L5
    Rat Ppp1r11 NM_212542 Q6MFY6
    PP1 12A Human PPP1R12A NM_002480 O14974
    Mouse Ppp1r12a NM_027892 Q9DBR7
    Rat Ppp1r12a NM_053890 Q10728
    PP1 12B Human PPP1R12B NM_032105 O60237
    Mouse Ppp1r12b NM_001081307 Q8BG95
    Rat Ppp1r12b NM_001107178 XP_222656
    PP1 12C Human PPP1R12C NM_017607 Q9BZL4
    Mouse Ppp1r12c NM_029834 Q3UMT1
    Rat Ppp1r12c XM_574359 XP_574359
    PP2α Human PPP2R5A NM_006243 Q15172
    Mouse Ppp2r5a NM_144880 Q6PD03
    Rat Ppp2r5a NM_001107891 XP_232413
    PP2β Human PPP2R5B NM_006244 Q15173
    Mouse Ppp2r5b NM_198168 NP_937811
    Rat Ppp2r5b NM_181379 Q80W83
    PP2γ Human PPP2R5C NM_178586 Q13362
    Mouse Ppp2r5c NM_012023 Q60996
    Rat Ppp2r5c XM_001077680 XP_001077680
    PP2δ Human PPP2R5D NM_180977 Q14738
    Mouse Ppp2r5d NM_009358 NP_033384
    Rat Ppp2r5d XM_001062510 Q499R1
    PP2ε Human PPP2R5E NM_006246 Q16537
    Mouse Ppp2r5e NM_012024 Q61151
    Rat Ppp2r5e NM_001106740 XP_216739
    PP2Aα Human PPP2CA NM_002715 P67775
    Mouse Ppp2ca NM_019411 P63330
    Rat Ppp2ca NM_017039 P63331
    PP2Aβ Human PPP2CB NM_004156 P62714
    Mouse Ppp2cb NM_017374 P62715
    Rat Ppp2cb NM_017040 P62716
    PP2A Aα Human PPP2R1A NM_014225 P30153
    Mouse Ppp2r1a NM_016891 Q76MZ3
    Rat Ppp2r1a NM_057140 O35511
    PP2A Aβ Human PPP2R1B NM_002716 P30154
    Mouse Ppp2r1b NM_001034085 Q7TNP2
    Rat Ppp2r1b NM_001025418 Q4QQT4
    PP2A Bα Human PPP2R2A NM_002717 P63151
    Mouse Ppp2r2a NM_028032 Q6P1F6
    Rat Ppp2r2a NM_053999 P36876
    PP2A Bβ Human PPP2R2B NM_181678 Q00005
    Mouse Ppp2r2b NM_028392 Q6ZWR4
    Rat Ppp2r2b NM_022209 P36877
    PP2A Bγ Human PPP2R2C NM_181876 Q9Y2T4
    Mouse Ppp2r2c NM_172994 Q8BG02
    Rat Ppp2r2c NM_057116 P97888
    PP2A Bδ Human PPP2R2D XM_352889 Q66LE6
    Mouse Ppp2r2d NM_026391 Q925E7
    Rat Ppp2r2d NM_144746 P56932
    PP3α Human PPP3CA NM_001130692 Q08209
    Mouse Ppp3ca NM_008913 P63328
    Rat Ppp3ca NM_017041 P63329
    PP3β Human PPP3CB NM_021132 P16298
    Mouse Ppp3cb NM_008914 P48453
    Rat Ppp3cb NM_017042 P20651
    PP3γ Human PPP3CC NM_005605 P48454
    Mouse Ppp3cc NM_008915 P48455
    Rat Ppp3cc NM_134367 Q04071
    PP3 Bα Human PPP3R1 NM_000945 P63098
    Mouse Ppp3r1 NM_024459 Q63810
    Rat Ppp3r1 NM_017309 P63100
    PP3 Bβ Human PPP3R2 NM_147180 Q96LZ3
    Mouse Ppp3r2 NM_001004025 Q63811
    Rat Ppp3r2 NM_021701 P28470
    PP4 Human PPP4C NM_002720 P60510
    Mouse Ppp4c NM_019674 P97470
    Rat Ppp4c NM_134359 Q04104
    PP4 1 Human PPP4R1 NM_001042388 Q8TF05
    Mouse Ppp4r1 NM_146081 Q8K2V1
    Rat Ppp4r1 NM_080907 Q8VI02
    PP4 2 Human PPP4R2 NM_174907 Q9NY27
    Mouse Ppp4r2 NM_182939 Q0VGB7
    Rat Ppp4r2 NM_001106613 XP_216225
    PP4 4 Human PPP4R4 NM_058237 Q6NUP7
    Mouse Ppp4r4 NM_028980 Q8C0Y0
    PP5 Human PPP5C NM_006247 P53041
    Mouse Ppp5c NM_011155 Q60676
    Rat Ppp5c NM_031729 P53042
    PP6 Human PPP6C NM_016294 O00743
    Mouse Ppp6c NM_024209 Q9CQR6
    Rat Ppp6c NM_133589 Q64620