INCA-6

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Cat.No. 2162 - INCA-6 | C20H12O2 | CAS No. 3519-82-2
Description: Inhibitor of calcineurin-substrate association
Chemical Name: 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature (1)

Biological Activity

Inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

Technical Data

M. Wt 284.31
Formula C20H12O2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 3519-82-2
PubChem ID 230748
InChI Key GCHPUOHXXCNSQL-UHFFFAOYSA-N
Smiles O=C1C=CC(=O)C2=C1C1C3=C(C=CC=C3)C2C2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.69 20

Preparing Stock Solutions

The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 17.59 mL 87.93 mL 175.86 mL
1 mM 3.52 mL 17.59 mL 35.17 mL
2 mM 1.76 mL 8.79 mL 17.59 mL
10 mM 0.35 mL 1.76 mL 3.52 mL

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References

References are publications that support the biological activity of the product.

Roehrl et al (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci.USA 101 7554


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Keywords: INCA-6, INCA-6 supplier, inhibitors, inhibits, calcineurin, Protein, Ser/Thr, Phosphatases, NFAT, 2162, Tocris Bioscience

3 Citations for INCA-6

Citations are publications that use Tocris products. Selected citations for INCA-6 include:

Savage et al (2015) RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα. PLoS One 10 e0116941 PMID: 25617622

Bretz et al (2015) NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis. Exp Eye Res 5 14963 PMID: 26527057

Faralli et al (2015) NFATc1 activity regulates the expression of myocilin induced by dexameth. Nat Chem Biol 130 42614 PMID: 25450062


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