Potent and selective cell-permeable inhibitor of protein phosphatase 1 (IC50 = 0.3 - 0.7 nM) and protein phosphatase 2A (IC50 = 0.5 - 1 nM). Displays > 10,000,000-fold selectivity over PP2B and PP2C.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1009.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.99 mL||4.95 mL||9.91 mL|
|5 mM||0.2 mL||0.99 mL||1.98 mL|
|10 mM||0.1 mL||0.5 mL||0.99 mL|
|50 mM||0.02 mL||0.1 mL||0.2 mL|
References are publications that support the products' biological activity.
Favre et al (1997) Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin. J.Biol.Chem. 272 13856 PMID: 9153244
Ishihara et al (1989) Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem.Biophys.Res.Commun. 159 871 PMID: 2539153
Lindval et al (1997) The binding mode of calyculin A to protein phosphatase-1. J.Biol.Chem. 272 23312 PMID: 9287341
McCluskey et al (2002) Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 45 1151 PMID: 11881984
If you know of a relevant reference for Calyculin A, please let us know.
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Keywords: Calyculin A, supplier, Protein, phosphatase, 1, 2A, inhibitors, inhibits, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, CalyculinA, Protein, Ser/Thr, Phosphatases, Protein, Ser/Thr, Phosphatases, Tocris Bioscience
2 Citations for Calyculin A
Citations are publications that use Tocris products. Selected citations for Calyculin A include:
Chazeau et al (2015) Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines. J Neurochem 26 859 PMID: 25568337
Isensee et al (2014) Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci 127 216 PMID: 24190886
Do you know of a great paper that uses Calyculin A from Tocris? If so please let us know.
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