Sanguinarine chloride

Pricing Availability Delivery Time Qty
Cat.No. 2302 - Sanguinarine chloride | C20H14ClNO4 | CAS No. 5578-73-4
Description: Inhibitor of protein phosphatase 2C (PP2C)
Chemical Name: 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride
Purity: ≥97% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

Inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.

Technical Data

M. Wt 367.78
Formula C20H14ClNO4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 5578-73-4
PubChem ID 68635
InChI Key GIZKAXHWLRYMLE-UHFFFAOYSA-M
Smiles C[N+]1=CC4=C(C=CC5=C4OCO5)C3=C1C2=CC(OCO6)=C6C=C2C=C3.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 3.68 10
ethanol 1.84 5

Preparing Stock Solutions

The following data is based on the product molecular weight 367.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.72 mL 13.6 mL 27.19 mL
5 mM 0.54 mL 2.72 mL 5.44 mL
10 mM 0.27 mL 1.36 mL 2.72 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Vogt et al (2005) The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1. J.Biol.Chem. 280 19078 PMID: 15753082

Aburai et al (2010) Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. Biosci.Biotechnol.Biochem. 74 548 PMID: 20208361

Adhami et al (2004) Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol.Cell Ther. 3 934 PMID:


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View Related Products by Product Action

View all Protein Ser/Thr Phosphatases Inhibitors

Keywords: Sanguinarine chloride, supplier, proapoptotic, anti-inflammatory, antioxidant, MKP-1, mitogen-activated, protein, kinase, phosphatase, inhibitors, blocks, cell, cycle, inhibits, protein, phosphase, 2C, PP2C, Protein, Ser/Thr, Phosphatases, Antioxidants, Protein, Ser/Thr, Phosphatases, Tocris Bioscience

3 Citations for Sanguinarine chloride

Citations are publications that use Tocris products. Selected citations for Sanguinarine chloride include:

Kenny et al (2015) Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. PLoS One 6 6220 PMID: 25653139

Bavaria et al (2014) The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis. Apoptosis 19 467 PMID: 24253595

Candas et al (2014) Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells. Cancer Res 74 7498 PMID: 25377473


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