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Inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 367.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||27.19 mL||135.95 mL||271.9 mL|
|0.5 mM||5.44 mL||27.19 mL||54.38 mL|
|1 mM||2.72 mL||13.6 mL||27.19 mL|
|5 mM||0.54 mL||2.72 mL||5.44 mL|
References are publications that support the biological activity of the product.
Vogt et al (2005) The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1. J.Biol.Chem. 280 19078 PMID: 15753082
Aburai et al (2010) Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. Biosci.Biotechnol.Biochem. 74 548 PMID: 20208361
Adhami et al (2004) Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol.Cell Ther. 3 934
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Keywords: Sanguinarine chloride, Sanguinarine chloride supplier, proapoptotic, anti-inflammatory, antioxidant, MKP-1, mitogen-activated, protein, kinase, phosphatase, inhibitors, blocks, cell, cycle, inhibits, phosphase, 2C, PP2C, Protein, Ser/Thr, Phosphatases, Antioxidants, 2302, Tocris Bioscience
4 Citations for Sanguinarine chloride
Citations are publications that use Tocris products. Selected citations for Sanguinarine chloride include:
Kenny et al (2015) Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. PLoS One 6 6220 PMID: 25653139
Pereira et al (2018) Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. Cell Rep 23 1124 PMID: 29694890
Bavaria et al (2014) The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis. Apoptosis 19 467 PMID: 24253595
Candas et al (2014) Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells. Cancer Res 74 7498 PMID: 25377473
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