Sanguinarine chloride

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Description: Inhibitor of protein phosphatase 2C (PP2C)
Chemical Name: 13-Methyl-[1,3]-benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium chloride
Purity: ≥97% (HPLC)
Citations (4)

Biological Activity for Sanguinarine chloride

Sanguinarine chloride is an inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Also inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) (IC50 = 10 μM). Plant alkaloid that exhibits anti-inflammatory and antioxidant activity. Blocks cell cycle in the G1 phase; inhibits cell growth in human prostate carcinoma cells.

Technical Data for Sanguinarine chloride

M. Wt 367.78
Formula C20H14ClNO4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 5578-73-4
PubChem ID 68635
Smiles C[N+]1=CC4=C(C=CC5=C4OCO5)C3=C1C2=CC(OCO6)=C6C=C2C=C3.[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sanguinarine chloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 3.68 10

Preparing Stock Solutions for Sanguinarine chloride

The following data is based on the product molecular weight 367.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.19 mL 135.95 mL 271.9 mL
0.5 mM 5.44 mL 27.19 mL 54.38 mL
1 mM 2.72 mL 13.6 mL 27.19 mL
5 mM 0.54 mL 2.72 mL 5.44 mL

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Product Datasheets for Sanguinarine chloride

References for Sanguinarine chloride

References are publications that support the biological activity of the product.

Vogt et al (2005) The benzo[c]phenanthridine alkaloid, sanguinarine, is a selective, cell-active inhibitor ofm mitogen-activated protein kinase phosphatase-1. J.Biol.Chem. 280 19078 PMID: 15753082

Aburai et al (2010) Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. Biosci.Biotechnol.Biochem. 74 548 PMID: 20208361

Adhami et al (2004) Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. Mol.Cell Ther. 3 934

If you know of a relevant reference for Sanguinarine chloride, please let us know.

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4 Citations for Sanguinarine chloride

Citations are publications that use Tocris products. Selected citations for Sanguinarine chloride include:

Pereira et al (2018) Infection Reveals a Modification of SIRT2 Critical for Chromatin Association. Cell Rep 23 1124 PMID: 29694890

Kenny et al (2015) Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. PLoS One 6 6220 PMID: 25653139

Bavaria et al (2014) The mechanism by which MEK/ERK regulates JNK and p38 activity in polyamine depleted IEC-6 cells during apoptosis. Apoptosis 19 467 PMID: 24253595

Candas et al (2014) Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells. Cancer Res 74 7498 PMID: 25377473

Do you know of a great paper that uses Sanguinarine chloride from Tocris? Please let us know.

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