Protein Tyrosine Phosphatases

Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinase and phosphorylase enzymes.

Products
Background
Literature
Gene Data

Inhibitors

Cat No Product Name / Activity
3979 Alexidine dihydrochloride
Selective inhibitor of PTPMT1
2176 BVT 948
Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signaling
5724 NQ 301
Selective CD45 inhibitor
2613 NSC 87877
Potent inhibitor of shp2 and shp1 PTP
5020 SF 1670
PTPN2 and PTEN inhibitor
2821 Sodium orthovanadate
Protein tyrosine phosphatase inhibitor
2754 TCS 401
Selective inhibitor of PTP1B
3591 VO-OHpic
Potent PTEN inhibitor

Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways, including histone dephosphorylation during epigenetic modification.

PTPs are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity. PTPs are currently divided into five subtypes: tyrosine-specific phosphatases (e.g. PTP1B); dual specificity phosphatases (DSPs) (e.g. DUSP1); Cdc25 phosphatases (e.g. Cdc25A); myotubularin-related phosphatases (e.g. MTMR13); and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity have been implicated in human diseases, including type II diabetes. PTPs have been identified as a negative regulator of insulin signaling due to its ability to dephosphorylate phosphotyrosine residues of insulin receptor kinase. In cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

Literature for Protein Tyrosine Phosphatases

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis

Protein Tyrosine Phosphatase Gene Data

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
PTP1B Human PTPN1 NM_002827 P18031
Mouse Ptpn1 NM_011201 P35821
Rat Ptpn1 NM_012637 P20417
DUSP1 Human DUSP1 NM_004417 P28562
Mouse Dusp1 NM_013642 P28563
Rat Dusp1 NM_053769 Q63683
Cdc25A Human CDC25A NM_001789 P30304
Mouse Cdc25a NM_007658 P48964
Rat Cdc25a NM_133571 P48965
MTMR13 Human SBF2 NM_030962 Q96FE2
Mouse Sbf2 AK173257 Q91VH0
PTPMT1 Human PTPMT1 XM_374879 BC014048
Mouse Ptpmt1 NM_025576 A2AFW5
Rat Ptpmt1 NM_001105726 NP_001099196