Protein Tyrosine Phosphatases

Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinase and phosphorylase enzymes.

Products
Background
Gene Data

Protein Tyrosine Phosphatases Inhibitors

Cat. No. Product Name / Activity
3979 Alexidine dihydrochloride
Selective inhibitor of PTPMT1
7481 BCI
DUSP6 and DUSP1 inhibitor
2176 BVT 948
Non-competitive protein tyrosine phosphatase inhibitor
6144 CX08005
Competitive PTP1B inhibitor
2613 NSC 87877
Potent inhibitor of shp2 and shp1 PTP
6771 PHPS1 sodium salt
Shp2 (PTPN11) inhibitor
5020 SF 1670
PTPN2 and PTEN inhibitor
2821 Sodium orthovanadate
Protein tyrosine phosphatase inhibitor
3591 VO-OHpic
Potent PTEN inhibitor

Protein tyrosine phosphatases (PTPs) are a group of enzymes that catalyze the removal of phosphate groups from tyrosine residues by the hydrolysis of phosphoric acid monoesters. They directly oppose the actions of kinases and phosphorylases and therefore play an integral role in many signal transduction pathways, including histone dephosphorylation during epigenetic modification.

PTPs are cysteine-dependent phosphatases that contain a conserved C[X]5R motif essential for enzymatic activity. PTPs are currently divided into five subtypes: tyrosine-specific phosphatases (e.g. PTP1B); dual specificity phosphatases (DSPs) (e.g. DUSP1); Cdc25 phosphatases (e.g. Cdc25A); myotubularin-related phosphatases (e.g. MTMR13); and low molecular weight phosphatases (e.g. PTPase A). Perturbations in PTP activity have been implicated in human diseases, including type II diabetes. In cancers, PTPs dephosphorylate EGFR, JAK2 and TYK2 kinases, promoting oncogenic transformation.

External sources of pharmacological information for Protein Tyrosine Phosphatases :

    Protein Tyrosine Phosphatase Gene Data

    Gene Species Gene Symbol Gene Accession No. Protein Accession No.
    PTP1B Human PTPN1 NM_002827 P18031
    Mouse Ptpn1 NM_011201 P35821
    Rat Ptpn1 NM_012637 P20417
    DUSP1 Human DUSP1 NM_004417 P28562
    Mouse Dusp1 NM_013642 P28563
    Rat Dusp1 NM_053769 Q63683
    Cdc25A Human CDC25A NM_001789 P30304
    Mouse Cdc25a NM_007658 P48964
    Rat Cdc25a NM_133571 P48965
    MTMR13 Human SBF2 NM_030962 Q96FE2
    Mouse Sbf2 AK173257 Q91VH0
    PTPMT1 Human PTPMT1 XM_374879 BC014048
    Mouse Ptpmt1 NM_025576 A2AFW5
    Rat Ptpmt1 NM_001105726 NP_001099196