Cyclosporin A

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Cat.No. 1101 - Cyclosporin A | C62H111N11O12 | CAS No. 59865-13-3
Description: Calcineurin inhibitor
Alternative Names: Ciclosporin A
Purity: ≥99% (HPLC)
Datasheet
Citations (13)
Literature

Biological Activity

Immunosuppressant; inhibits phosphatase activity of calcineurin (IC50 = 5 nM). Also inhibits formation and opening of the mitochondrial permeability transition pore (MPTP).

Compound Libraries

Cyclosporin A is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 1202.63
Formula C62H111N11O12
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 59865-13-3
PubChem ID 2909
InChI Key PMATZTZNYRCHOR-UHFFFAOYSA-N
Smiles OC(C(CC=CC)C)C1C(=O)NC(C(=O)N(C)CC(N(C)C(CC(C)C)C(NC(C(=O)N(C)C(CC(C)C)C(NC(C)C(=O)NC(C)C(N(C)C(C(N(C)C(C(N(C)C(C(C)C)C(=O)N1C)=O)CC(C)C)=O)CC(C)C)=O)=O)C(C)C)=O)=O)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 120.26 100
ethanol 60.13 50

Preparing Stock Solutions

The following data is based on the product molecular weight 1202.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.83 mL 4.16 mL 8.32 mL
5 mM 0.17 mL 0.83 mL 1.66 mL
10 mM 0.08 mL 0.42 mL 0.83 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Brookemeier and Pfeiffer (1995) Inhibition of the mitochondrial permeability transition pore by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases. Biochemistry 34 16440 PMID: 8845372

Fruman et al (1992) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc.Natl.Acad.Sci.U.S.A. 89 3686 PMID: 1373887

Nakata et al (1998) Evidence that cyclosporin A and dexamethasone inhibit allergic airway inflammation via suppression of interleukin-5 synthesis by T cells. Br.J.Pharmacol. 124 1425 PMID: 9723954

Yan et al (2009) Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells. BiochemsBiophys.Res.Commun. 379 115 PMID: 19094963


If you know of a relevant reference for Cyclosporin A, please let us know.

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13 Citations for Cyclosporin A

Citations are publications that use Tocris products. Selected citations for Cyclosporin A include:

Gross et al (2013) Roles of endothelial nitric oxide synthase (eNOS) and mitochondrial permeability transition pore (MPTP) in epoxyeicosatrienoic acid (EET)-induced cardioprotection against infarction in intact rat hearts. J Mol Cell Cardiol 59 20 PMID: 23419451

Pont et al (2012) Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol.Endocrinol. 26 1743 PMID: 22902539

Li and Burrell (2011) Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms. Learn Mem 18 545 PMID: 21844187

George et al (2011) Calcium-dependent phosphorylation regulates neuronal stability and plasticity in a highly precise pacemaker nucleus. J Neurophysiol 106 319 PMID: 21525377

Grodzki et al (2009) FcεRI-induced activation by low antigen concentrations results in nuclear signals in the absence of degranulation. PLoS One 46 2539 PMID: 19540596

Belmeguenai and Hansel (2005) A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation. J Biol Chem 25 10768 PMID: 16291950

Miyamoto et al (2016) Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. Cardiorenal Med 291 1719 PMID: 26589795

Piccart et al (2015) Neurotensin Induces Presynaptic Depression of D2 Dopamine Autoreceptor-Mediated Neurotransmission in Midbrain Dopaminergic Neurons. J Neurosci 35 11144 PMID: 26245975

Liu et al (2015) Hyperphosphate-Induced Myocardial Hypertrophy through the GATA-4/NFAT-3 Signaling Pathway Is Attenuated by ERK Inhibitor Treatment. Exp Eye Res 5 79 PMID: 25999956

Faralli et al (2015) NFATc1 activity regulates the expression of myocilin induced by dexamethasone. J Biol Chem 130 42614 PMID: 25450062

Draganov et al (2015) Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. J Neurosci 5 16222 PMID: 26552848

Yu et al (2014) Differential effects of the Toll-like receptor 2 agonists, PGN and Pam3CSK4 on anti-IgE induced human mast cell activation. PLoS One 9 e112989 PMID: 25398056

Gray et al (2014) Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits. Mol Immunol 289 14600 PMID: 24706758


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Pathways for Cyclosporin A

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