Ceramide

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Cat.No. 0744 - Ceramide | C20H39NO3 | CAS No. 3102-57-6
Description: Ser/Thr protein phosphatase activator
Chemical Name: N-Acetylsphingosine
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

A potent modulator of cell proliferation and differentiation. Activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro.

Compound Libraries

Ceramide is also offered as part of the Tocriscreen Stem Cell Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 341.53
Formula C20H39NO3
Storage Desiccate at -20°C
CAS Number 3102-57-6
PubChem ID 5497136
InChI Key BLTCBVOJNNKFKC-QUDYQQOWSA-N
Smiles OC[C@@](NC(C)=O)([H])[C@H](O)/C([H])=C([H])/CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 34.15 100
DMSO 34.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 341.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.64 mL 29.28 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
10 mM 0.29 mL 1.46 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Dobowsky and Hannun (1992) Ceramide stimulates a cytosolic protein phosphatase. J.Biol.Chem. 267 5048 PMID: 1312082

Kim et al (1991) Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor α and γ-IF.. J.Biol.Chem. 266 484 PMID: 1845977

Quintans et al (1994) Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem.Biophys.Res.Commun. 202 710 PMID: 8048941

Xie and Johnson (1997) Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I. J.Neurochem. 69 1020 PMID: 9282924


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Keywords: Ceramide, Ceramide supplier, Ser/Thr, protein, phosphatase, activators, Protein, Phosphatases, 0744, Tocris Bioscience

1 Citation for Ceramide

Citations are publications that use Tocris products. Selected citations for Ceramide include:

Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Pharmacol Biochem Behav 232 44105 PMID: 25300478


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

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