Sephin 1

Pricing Availability Delivery Time Qty
Cat.No. 5553 - Sephin 1 | C8H9ClN4.CH2O3
Description: Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1
Chemical Name: (2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1. Does not bind PPP1R15B or have α2 adrenergic agonist activity. Cytoprotective in endoplasmic reticulum stressed cells in vitro. Prevents defects associated with protein misfolding in a mouse Charcot-Marie Tooth-1B model. Orally available.

Technical Data

M. Wt 258.66
Formula C8H9ClN4.CH2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 121513868
InChI Key LCQVFBONUDQAEH-NKPNRJPBSA-N
Smiles ClC1=C(/C=N/NC(N)=N)C=CC=C1.OC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.87 100

Preparing Stock Solutions

The following data is based on the product molecular weight 258.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.87 mL 19.33 mL 38.66 mL
5 mM 0.77 mL 3.87 mL 7.73 mL
10 mM 0.39 mL 1.93 mL 3.87 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Das et al (2015) Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348 239 PMID: 25859045


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Keywords: Sephin 1, supplier, Sephin1, protein, phosphatases, 1, PPP1R115A, serine/threonine, protein, folding, Charcot-Marie, Tooth, 1B, CMT1B, inhibitors, orally, available, inhibits, 951441-04-6, Protein, Ser/Thr, Phosphatases, Protein, Ser/Thr, Phosphatases, Tocris Bioscience

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