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Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1. Does not bind PPP1R15B or have α2 adrenergic agonist activity. Cytoprotective in endoplasmic reticulum stressed cells in vitro. Prevents defects associated with protein misfolding in a mouse Charcot-Marie Tooth-1B model. Orally available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 258.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.87 mL||19.33 mL||38.66 mL|
|5 mM||0.77 mL||3.87 mL||7.73 mL|
|10 mM||0.39 mL||1.93 mL||3.87 mL|
|50 mM||0.08 mL||0.39 mL||0.77 mL|
References are publications that support the biological activity of the product.
Das et al (2015) Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348 239 PMID: 25859045
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Keywords: Sephin 1, Sephin 1 supplier, Sephin1, protein, phosphatases, 1, PPP1R115A, serine/threonine, folding, Charcot-Marie, Tooth, 1B, CMT1B, inhibitors, orally, available, inhibits, 951441-04-6, Protein, Ser/Thr, Phosphatases, 5553, Tocris Bioscience
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