Sephin 1

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Description: Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1
Chemical Name: (2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt
Purity: ≥98% (HPLC)

Biological Activity for Sephin 1

Sephin 1 is an inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1. Does not bind PPP1R15B or have α2 adrenergic agonist activity. Cytoprotective in endoplasmic reticulum stressed cells in vitro. Prevents defects associated with protein misfolding in a mouse Charcot-Marie Tooth-1B model. Orally available.

Compound Libraries for Sephin 1

Sephin 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for Sephin 1

M. Wt 258.66
Formula C8H9ClN4.CH2O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1883549-35-6
PubChem ID 121513868
Smiles ClC1=C(/C=N/NC(N)=N)C=CC=C1.OC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Sephin 1

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 25.87 100

Preparing Stock Solutions for Sephin 1

The following data is based on the product molecular weight 258.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.87 mL 19.33 mL 38.66 mL
5 mM 0.77 mL 3.87 mL 7.73 mL
10 mM 0.39 mL 1.93 mL 3.87 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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References for Sephin 1

References are publications that support the biological activity of the product.

Das et al (2015) Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348 239 PMID: 25859045

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Keywords: Sephin 1, Sephin 1 supplier, Sephin1, protein, phosphatases, 1, PPP1R115A, serine/threonine, folding, Charcot-Marie, Tooth, 1B, CMT1B, inhibitors, orally, available, inhibits, 951441-04-6, Protein, Ser/Thr, Phosphatases, 5553, Tocris Bioscience

Citations for Sephin 1

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