Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1. Does not bind PPP1R15B or have α2 adrenergic agonist activity. Cytoprotective in endoplasmic reticulum stressed cells in vitro. Prevents defects associated with protein misfolding in a mouse Charcot-Marie Tooth-1B model. Orally available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 258.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.87 mL||19.33 mL||38.66 mL|
|5 mM||0.77 mL||3.87 mL||7.73 mL|
|10 mM||0.39 mL||1.93 mL||3.87 mL|
|50 mM||0.08 mL||0.39 mL||0.77 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Das et al (2015) Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348 239 PMID: 25859045
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Keywords: Sephin1 protein phosphatases 1 PPP1R115A serine/threonine protein folding Charcot-Marie Tooth 1B CMT1B inhibitors orally available inhibits 951441-04-6 Protein Ser/Thr Phosphatases
Citations for Sephin 1
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