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Human pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Increases hPXR target gene expression in human hepatocyte primary cultures. Also acts as a histamine H1 receptor antagonist. Confers neuroprotection in models of polyQ toxicity.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 463.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.31 mL||21.56 mL||43.12 mL|
|2.5 mM||0.86 mL||4.31 mL||8.62 mL|
|5 mM||0.43 mL||2.16 mL||4.31 mL|
|25 mM||0.09 mL||0.43 mL||0.86 mL|
References are publications that support the biological activity of the product.
Parada et al (2001) The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 102 937 PMID: 11182255
Gohil et al (2010) Meclizine is neuroprotective in models of Huntington's disease. Hum.Mol.Genet. 20 294 PMID: 20977989
Lau et al (2011) Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. J.Pharmacol.Exp.Ther. 336 816 PMID: 21131266
If you know of a relevant reference for Meclizine dihydrochloride, please let us know.
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Keywords: Meclizine dihydrochloride, Meclizine dihydrochloride supplier, antihistamine, histaminergic, pregnane, x, receptors, pxr, hpxr, agonists, activators, neuroprotective, neuroprotectants, meclozine, Meclozine, Histamine, H1, Receptors, Pregnane, X, Receptor, 4245, Tocris Bioscience
1 Citation for Meclizine dihydrochloride
Citations are publications that use Tocris products. Selected citations for Meclizine dihydrochloride include:
Hong et al (2016) Meclizine-induced enhanced glycolysis is neuroprotective in Parkinson disease cell models. Sci Rep 6 25344 PMID: 27145922
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