Human pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Increases hPXR target gene expression in human hepatocyte primary cultures. Also acts as a histamine H1 receptor antagonist. Confers neuroprotection in models of polyQ toxicity.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 463.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.16 mL||10.78 mL||21.56 mL|
|5 mM||0.43 mL||2.16 mL||4.31 mL|
|10 mM||0.22 mL||1.08 mL||2.16 mL|
|50 mM||0.04 mL||0.22 mL||0.43 mL|
References are publications that support the biological activity of the product.
Parada et al (2001) The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 102 937 PMID: 11182255
Gohil et al (2010) Meclizine is neuroprotective in models of Huntington's disease. Hum.Mol.Genet. 20 294 PMID: 20977989
Lau et al (2011) Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. J.Pharmacol.Exp.Ther. 336 816 PMID: 21131266
If you know of a relevant reference for Meclizine dihydrochloride, please let us know.
View Related Products by Product Action
Keywords: Meclizine dihydrochloride, Meclizine dihydrochloride supplier, antihistamine, histaminergic, pregnane, x, receptors, pxr, hpxr, agonists, activators, neuroprotective, neuroprotectants, meclozine, Meclozine, Histamine, H1, Receptors, Pregnane, X, Receptor, 4245, Tocris Bioscience
Citations for Meclizine dihydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Meclizine dihydrochloride. Do you know of a great paper that uses Meclizine dihydrochloride from Tocris? Please let us know.
Reviews for Meclizine dihydrochloride
There are currently no reviews for this product. Be the first to review Meclizine dihydrochloride and earn rewards!
Have you used Meclizine dihydrochloride?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.