Meclizine dihydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 4245 - Meclizine dihydrochloride | C25H27ClN2.2HCl | CAS No. 1104-22-9
Description: Human pregnane X receptor agonist; H1 antagonist
Alternative Names: Meclozine
Chemical Name: 1-[(4-Chlorophenyl)phenylmethyl]4-[(3-methylphenyl)methyl]piperazine dihydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Human pregnane X receptor (hPXR) agonist; stronger activator of hPXR than rat PXR. Increases hPXR target gene expression in human hepatocyte primary cultures. Also acts as a histamine H1 receptor antagonist. Confers neuroprotection in models of polyQ toxicity.

Compound Libraries

Meclizine dihydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 463.87
Formula C25H27ClN2.2HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1104-22-9
PubChem ID 64713
InChI Key VCTHNOIYJIXQLV-UHFFFAOYSA-N
Smiles CC1=CC(CN(CC4)CCN4C(C3=CC=C(Cl)C=C3)C2=CC=CC=C2)=CC=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.19 50

Preparing Stock Solutions

The following data is based on the product molecular weight 463.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.78 mL 21.56 mL
5 mM 0.43 mL 2.16 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Parada et al (2001) The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 102 937 PMID: 11182255

Gohil et al (2010) Meclizine is neuroprotective in models of Huntington's disease. Hum.Mol.Genet. 20 294 PMID: 20977989

Lau et al (2011) Differential effect of meclizine on the activity of human pregnane X receptor and constitutive androstane receptor. J.Pharmacol.Exp.Ther. 336 816 PMID: 21131266


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Citations for Meclizine dihydrochloride

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Nuclear Receptors

Nuclear Receptors Product Listing

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Retinoid Receptors

Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.

Pathways for Meclizine dihydrochloride

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