L-type calcium channel blocker.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 346.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.89 mL||14.44 mL||28.87 mL|
|5 mM||0.58 mL||2.89 mL||5.77 mL|
|10 mM||0.29 mL||1.44 mL||2.89 mL|
|50 mM||0.06 mL||0.29 mL||0.58 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Stork and Cocks (1994) Pharmacological reactivity of human epicardial coronary arteries: phasic and tonic responses to vasoconstrictor agents differentiated by nifedipine. Br.J.Pharmacol. 113 1093 PMID: 7889259
If you know of a relevant reference for Nifedipine, please let us know.
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Keywords: Ca2+ channel blockers L-type Calcium CaV Channels voltage-gated voltage-dependent Voltage-gated Calcium Channels
21 Citations for Nifedipine
Citations are publications that use Tocris products. Selected citations for Nifedipine include:
Kaufman et al (2012) Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. Mol Brain 32 3992 PMID: 22442066
Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176
Luoma et al (2011) Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids 76 845 PMID: 21371490
Abe et al (2011) The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells. Mol Brain 108 12497 PMID: 21746923
Landstrom et al (2011) Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. FEMS Immunol Med Microbiol 4 214 PMID: 21216834
Xu et al (2011) Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes. Mol Cells 406 200 PMID: 21303662
Kim and Rhim (2011) Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels. Proc Natl Acad Sci U S A 32 289 PMID: 21822937
Kyriazis et al (2010) Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel. J Biol Chem 285 6811 PMID: 20038578
Potier et al (2010) Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging. Front Aging Neurosci 2 1 PMID: 20552041
Maier et al (2010) Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation. J Biol Chem 285 35606 PMID: 20826795
Large et al (2010) Ionic currents in intimal cultured synoviocytes from the rabbit. Am J Physiol Cell Physiol 299 C1180 PMID: 20720182
Ludwar et al (2009) Two distinct mechanisms mediate potentiating effects of depolarization on synaptic transmission. J Neurophysiol 102 1976 PMID: 19605611
Shin et al (2008) Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells. Proc Natl Acad Sci U S A 105 746 PMID: 18174329
Soriano et al (2008) Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. Biochem Biophys Res Commun 28 10696 PMID: 18923045
Wieland et al (2006) Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels. J Neurosci 47 296 PMID: 16831218
Fujino et al (2003) Regulation of cpg15 by signaling pathways that mediate synaptic plasticity. Mol Cell Neurosci 24 538 PMID: 14664806
Bellono (2017) Molecular basis of ancestral vertebrate electroreception. Nature 543 391 PMID: 28264196
Lee et al (2015) N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity. J Neurosci 8 4 PMID: 25599691
Armstrong and Drapeau (2013) Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS. Circ Heart Fail 33 1741 PMID: 23345247
Ring et al (2012) GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7 e36874 PMID: 22590629
Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285 PMID: 22368777
Do you know of a great paper that uses Nifedipine from Tocris? If so please let us know.
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.