Carbetocin

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Cat.No. 4852 - Carbetocin | Butyryl-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 | CAS No. 37025-55-1
Description: Oxytocin analog
Datasheet
Citations
Literature

Biological Activity

Oxytocin analog. Long-acting; displays agonist properties.

Technical Data

M. Wt 988.17
Formula C45H69N11O12S
Sequence XYIQNCPLG

(Modifications: X = Butanoic acid, Gly-9 = C-terminal amide, Tyr-2 = Me-Tyr, Carba sulfide bridge between X-1 - Cys-6)

Storage Store at -20°C
CAS Number 37025-55-1
PubChem ID 71715
InChI Key SMMBGKXBHJTULT-DTRKZRJBSA-N
Smiles CC[C@H](C)[C@@H]1NC(=O)[C@H](CC2=CC=C(O)C=C2)N(C)C(=O)CCCSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 29.65 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 988.17. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.01 mL 5.06 mL 10.12 mL
5 mM 0.2 mL 1.01 mL 2.02 mL
10 mM 0.1 mL 0.51 mL 1.01 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Su et al (2012) Carbetocin for preventing postpartum haemorrhage. Cochrane Database Syst.Rev. PMID: 22513931

Holleboom et al (2013) Carbetocin in comparison with oxytocin in several dosing regimens for the prevention of uterine atony after elective caesarean section in the Netherlands. Arch.Gynecol.Obstet. Epub ahead of print PMID: 23329341


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Keywords: Oxytocin analog octapeptide agonists Oxytocin Receptors

Citations for Carbetocin

Citations are publications that use Tocris products.

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Literature in this Area

GPCR

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Pathways for Carbetocin

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