WAY 267464 dihydrochloride

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Cat.No. 3933 - WAY 267464 dihydrochloride | C32H35N7O4.2HCl | CAS No. 1432043-31-6
Description: Potent non-peptide oxytocin receptor agonist
Chemical Name: N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-4-[(3,5-dihydroxyphenyl)methyl]-1-piperazinecarboxamide dihydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent, selective non-peptide oxytocin receptor (OTR) agonist (Ki = 58.4 nM at human OTR). Exhibits anxiolytic-like effects. May have therapeutic potential for the treatment of psychosis and schizophrenia.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 654.59
Formula C32H35N7O4.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1432043-31-6
PubChem ID 71555165
InChI Key OTFWXMFLPMUDFP-UHFFFAOYSA-N
Smiles CN(N=C3)C1=C3CN(C(C4=CC=C(CNC(N5CCN(CC6=CC(O)=CC(O)=C6)CC5)=O)C(C)=C4)=O)C(C=CC=C2)=C2N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.37 80
water 3.27 5

Preparing Stock Solutions

The following data is based on the product molecular weight 654.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.53 mL 7.64 mL 15.28 mL
5 mM 0.31 mL 1.53 mL 3.06 mL
10 mM 0.15 mL 0.76 mL 1.53 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Ring et al (2010) Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist. Neuropharmacology 58 6 PMID: 19615387


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