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WAY 267464 dihydrochloride
Biological Activity for WAY 267464 dihydrochloride
WAY 267464 dihydrochloride is a potent, selective non-peptide oxytocin receptor (OTR) agonist (Ki = 58.4 nM at human OTR). Exhibits anxiolytic-like effects. May have therapeutic potential for the treatment of psychosis and schizophrenia.
Sold for research purposes under agreement from Pfizer Inc.
Technical Data for WAY 267464 dihydrochloride
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for WAY 267464 dihydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for WAY 267464 dihydrochloride
The following data is based on the product molecular weight 654.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.8 mM||1.91 mL||9.55 mL||19.1 mL|
|4 mM||0.38 mL||1.91 mL||3.82 mL|
|8 mM||0.19 mL||0.95 mL||1.91 mL|
|40 mM||0.04 mL||0.19 mL||0.38 mL|
Product Datasheets for WAY 267464 dihydrochloride
References for WAY 267464 dihydrochloride
References are publications that support the biological activity of the product.
Ring et al (2010) Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxyt. receptor agonist. Neuropharmacology 58 6 PMID: 19615387
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Keywords: WAY 267464 dihydrochloride, WAY 267464 dihydrochloride supplier, WAY267464, dihydrochloride, oxytocin, agonists, OT, receptors, non-peptide, pfizer, Oxytocin, Receptors, 3933, Tocris Bioscience
5 Citations for WAY 267464 dihydrochloride
Citations are publications that use Tocris products. Selected citations for WAY 267464 dihydrochloride include:
Sandy et al (2022) Social isolation modulates appetite and avoidance behavior via a common oxytocinergic circuit in larval zebrafish. Nat Commun 13 2573 PMID: 35545618
Xiao et al (2017) Biased OXTergic Modulation of Midbrain DA Systems. Neuron 95 368 PMID: 28669546
Akihiro et al (2020) Physiological and pharmacological evaluation of oxytocin-induced milk ejection in mice. Exp Anim 69 345-353 PMID: 32213759
Tzu-Ming et al (2020) Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein-Coupled Receptor Signaling for Fibrosis. J Pharmacol Exp Ther 375 357-366 PMID: 32848074
Huo et al (2018) Tph2-/- female mice restore socio-sexual recognition through upregulating ERα and OTR genes in the amygdala. PLoS One 13 e0193395 PMID: 29470551
Do you know of a great paper that uses WAY 267464 dihydrochloride from Tocris? Please let us know.
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