WAY 267464 dihydrochloride

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Cat.No. 3933 - WAY 267464 dihydrochloride | C32H35N7O4.2HCl | CAS No. 1432043-31-6
Description: Potent non-peptide oxytocin receptor agonist
Chemical Name: N-[[4-[(4,10-Dihydro-1-methylpyrazolo[3,4-b][1,5]benzodiazepin-5(1H)-yl)carbonyl]-2-methylphenyl]methyl]-4-[(3,5-dihydroxyphenyl)methyl]-1-piperazinecarboxamide dihydrochloride
Purity: ≥97% (HPLC)
Citations (2)
Literature (2)

Biological Activity for WAY 267464 dihydrochloride

WAY 267464 dihydrochloride is a potent, selective non-peptide oxytocin receptor (OTR) agonist (Ki = 58.4 nM at human OTR). Exhibits anxiolytic-like effects. May have therapeutic potential for the treatment of psychosis and schizophrenia.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for WAY 267464 dihydrochloride

M. Wt 654.59
Formula C32H35N7O4.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1432043-31-6
PubChem ID 71555165
Smiles CN(N=C3)C1=C3CN(C(C4=CC=C(CNC(N5CCN(CC6=CC(O)=CC(O)=C6)CC5)=O)C(C)=C4)=O)C(C=CC=C2)=C2N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WAY 267464 dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 52.37 80
water 3.27 5

Preparing Stock Solutions for WAY 267464 dihydrochloride

The following data is based on the product molecular weight 654.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.8 mM 1.91 mL 9.55 mL 19.1 mL
4 mM 0.38 mL 1.91 mL 3.82 mL
8 mM 0.19 mL 0.95 mL 1.91 mL
40 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets for WAY 267464 dihydrochloride

Certificate of Analysis / Product Datasheet
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References for WAY 267464 dihydrochloride

References are publications that support the biological activity of the product.

Ring et al (2010) Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxyt. receptor agonist. Neuropharmacology 58 6 PMID: 19615387

If you know of a relevant reference for WAY 267464 dihydrochloride, please let us know.

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Keywords: WAY 267464 dihydrochloride, WAY 267464 dihydrochloride supplier, WAY267464, dihydrochloride, oxytocin, agonists, OT, receptors, non-peptide, pfizer, Oxytocin, Receptors, 3933, Tocris Bioscience

2 Citations for WAY 267464 dihydrochloride

Citations are publications that use Tocris products. Selected citations for WAY 267464 dihydrochloride include:

Huo et al (2018) Tph2-/- female mice restore socio-sexual recognition through upregulating ERα and OTR genes in the amygdala. PLoS One 13 e0193395 PMID: 29470551

Xiao et al (2017) Biased OXTergic Modulation of Midbrain DA Systems. Neuron 95 368 PMID: 28669546

Do you know of a great paper that uses WAY 267464 dihydrochloride from Tocris? Please let us know.

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Literature in this Area

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