Atosiban

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Description: Potent oxytocin receptor antagonist
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews (1)

Biological Activity for Atosiban

Atosiban is a potent oxytocin receptor (OTR) antagonist. Inhibits oxytocin-induced increase in Ca2+ concentration in myometrial cells in vitro (IC50 = 5 nM) Activates NF-κB and MAPK pathways in human amnion via Gαi signaling, resulting in pro-inflammatory effects. Inhibits oxytocin-induced uterine contractions in vivo and in vitro. Effective in a rat preterm labor model.

Technical Data for Atosiban

M. Wt 994.19
Formula C43H67N11O12S2
Sequence XYITNCPXG

(Modifications: X-1 = Mpr, Tyr-2 = D-Tyr(OEt), X-8 = Orn, Gly-9 = C-terminal amide, Cyclized: X-1 - Cys-6)

Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 90779-69-4
PubChem ID 5311010
InChI Key VWXRQYYUEIYXCZ-OBIMUBPZSA-N
Smiles [H][C@@]1([C@H](O)C)NC(C([C@H](CC)C)NC([C@H](NC(CCSSC[C@@H](C(N2CCC[C@H]2C(N[C@H](C(NCC(N)=O)=O)CCCN)=O)=O)NC([C@@H](NC1=O)CC(N)=O)=O)=O)CC3=CC=C(C=C3)OCC)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Atosiban

Solubility Soluble to 50 mg/ml in water

Product Datasheets for Atosiban

Certificate of Analysis / Product Datasheet
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References for Atosiban

References are publications that support the biological activity of the product.

Kim et al (2016) The oxyt. receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via Gαi signalling. Mol.Cell.Endocrinol. 420 11 PMID: 26586210

Kim et al (2017) Differential effects of oxyt. receptor antagonists, Atosiban and Nolasiban, on oxyt. receptor-mediated signaling in human amnion and myometrium. Mol.Pharmacol. 91 403 PMID: 28188254

Hahn et al (1987) Evaluation of 1-deamino-[D-Tyr(Oethyl)2, Thr4, Orn8] vasotocin, an oxyt. antagonist, in animal models of uterine contractility and preterm labor: a new tocolytic agent. Am.J.Obstet.Gynecol. 157 977 PMID: 3674173

Maggi et al (1994) Antagonists for the human oxyt. receptor: an in vitro study. J.Reprod.Fertil. 101 345 PMID: 7932368


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Keywords: Atosiban, Atosiban supplier, oxytoxin, receptor, antagonists, antagonism, tocolytics, preterm, labor, labour, OTR, Oxytocin, Receptors, 6332, Tocris Bioscience

4 Citations for Atosiban

Citations are publications that use Tocris products. Selected citations for Atosiban include:

Silke et al (2022) Oxytocin accelerates tight junction formation and impairs cellular migration in 3D spheroids: evidence from Gapmer-induced exon skipping. Front Cell Neurosci 16 1000538 PMID: 36263085

Li et al (2021) Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation Cell Rep 36 109411 PMID: 34289348

Xiaobing et al (2021) Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology 46 1045-1056 PMID: 33495546

Yoshiyuki et al (2020) Oxytocin-Dependent Regulation of TRPs Expression in Trigeminal Ganglion Neurons Attenuates Orofacial Neuropathic Pain Following Infraorbital Nerve Injury in Rats. Int J Mol Sci 21 PMID: 33271955


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Reviews for Atosiban

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Inhibition of oxytocin receptor.
By Mohammad Alqudah on 10/19/2022
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Smooth muscle

10 uM of atosiban 10 to 15 min in an organ bath to block oxytocin-induced contraction of gut smooth muscle strips

review image