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Cat.No. 6332 - Atosiban | Mpr-D-Tyr(OEt)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 | CAS No. 90779-69-4
Description: Potent oxytocin receptor antagonist

Biological Activity

Potent oxytocin receptor (OTR) antagonist. Inhibits oxytocin-induced increase in Ca2+ concentration in myometrial cells in vitro (IC50 = 5 nM) Activates NF-κB and MAPK pathways in human amnion via Gαi signaling, resulting in pro-inflammatory effects. Inhibits oxytocin-induced uterine contractions in vivo and in vitro. Effective in a rat preterm labor model.

Technical Data

M. Wt 994.19
Formula C43H67N11O12S2

(Modifications: X-1 = Mpr, X-8 = Orn, Tyr-2 = D-Tyr(OEt), Gly-9 = C-terminal amide, Cyclized = X-1 - Cys-6)

Storage Store at -20°C
CAS Number 90779-69-4
PubChem ID 5311010
Smiles [H][C@@]1([C@H](O)C)NC(C([C@H](CC)C)NC([C@H](NC(CCSSC[C@@H](C(N2CCC[C@H]2C(N[C@H](C(NCC(N)=O)=O)CCCN)=O)=O)NC([C@@H](NC1=O)CC(N)=O)=O)=O)CC3=CC=C(C=C3)OCC)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 994.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.01 mL 5.03 mL 10.06 mL
5 mM 0.2 mL 1.01 mL 2.01 mL
10 mM 0.1 mL 0.5 mL 1.01 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Kim et al (2016) The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via Gαi signalling. Mol.Cell.Endocrinol. 420 11 PMID: 26586210

Kim et al (2017) Differential effects of oxytocin receptor antagonists, Atosiban and Nolasiban, on oxytocin receptor-mediated signaling in human amnion and myometrium. Mol.Pharmacol. 91 403 PMID: 28188254

Hahn et al (1987) Evaluation of 1-deamino-[D-Tyr(Oethyl)2, Thr4, Orn8] vasotocin, an oxytocin antagonist, in animal models of uterine contractility and preterm labor: a new tocolytic agent. Am.J.Obstet.Gynecol. 157 977 PMID: 3674173

Maggi et al (1994) Antagonists for the human oxytocin receptor: an in vitro study. J.Reprod.Fertil. 101 345 PMID: 7932368

If you know of a relevant reference for Atosiban, please let us know.

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Keywords: Atosiban, supplier, oxytoxin, receptor, antagonists, antagonism, tocolytics, preterm, labor, labour, OTR, Oxytocin, Receptors, Oxytocin, Receptors, Tocris Bioscience

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