L-368,899 hydrochloride

Pricing Availability   Qty

15% Off Limited-time Savings on Your Reagents, Assays, and Kits
Now through September 27th, you can save 15% on Bio-Techne reagents, assays, and kits (including Novus, Tocris, and R&D Systems). Use promotion code SAVE15 at checkout on orders over $1,000. See terms and conditions for offer details.

Cat.No. 2641 - L-368,899 hydrochloride | C26H42N4O5S2.HCl | CAS No. 160312-62-9
Description: Potent, non-peptide oxytocin receptor antagonist
Chemical Name: (2S)-2-Amino-N-[(1S,2S,4R)-7,7-dimethyl-1-[[[4-(2-methylphenyl)-1-piperazinyl]sulfonyl]methyl]bicyclo[2.2.1]hept-2-yl]-4-(methylsulfonyl)butanamide
Purity: ≥97% (HPLC)
Citations (4)
Reviews (1)
Literature (2)

Biological Activity for L-368,899 hydrochloride

L-368,899 hydrochloride is a potent, non-peptide and orally active oxytocin receptor antagonist (IC50 = 8.9 nM) that displays > 40-fold selectivity over vasopressin V1a and V2 receptors (IC50 values are 370 and 570 nM respectively). Antagonizes oxytocin-induced uterine contractions in vitro and in vivo.

Compound Libraries for L-368,899 hydrochloride

L-368,899 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for L-368,899 hydrochloride

M. Wt 591.23
Formula C26H42N4O5S2.HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 160312-62-9
PubChem ID 90488775
Smiles CC(C=CC=C2)=C2N1CCN(S(CC34CCC(C(C)4C)C[C@@H]3NC([C@@H](N)CCS(C)(=O)=O)=O)(=O)=O)CC1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for L-368,899 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 59.12 100
DMSO 59.12 100

Preparing Stock Solutions for L-368,899 hydrochloride

The following data is based on the product molecular weight 591.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.69 mL 8.46 mL 16.91 mL
5 mM 0.34 mL 1.69 mL 3.38 mL
10 mM 0.17 mL 0.85 mL 1.69 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for L-368,899 hydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:

References for L-368,899 hydrochloride

References are publications that support the biological activity of the product.

Williams et al (1994) 1-(((7,7-dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2.2.1]-heptan-1(S)-yl)methyl)sulfonyl)-4-(2-methylphenyl)piperazine (L-368,899): an orally bioavailable, non-peptide oxyt. antagonist with potential util J.Med.Chem. 37 565 PMID: 8126695

Mann et al (2003) Attenuation of PGE release in ewes infused with the oxyt. antagonist L-368,899. Domest.Anim.Endocrinol. 25 255 PMID: 14550509

Quattropani et al (2005) Discovery and development of a new class of potent, selective, orally active oxyt. receptor antagonist. J.Med.Chem. 48 7882 PMID: 16302826

Borthwick (2010) Oral oxyt. antagonists. J.Med.Chem. 53 6525 PMID: 20550119

If you know of a relevant reference for L-368,899 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Oxytocin Receptor Antagonists

Keywords: L-368,899 hydrochloride, L-368,899 hydrochloride supplier, Potent, non-peptide, oxytocin, receptor, antagonists, OT, Receptors, L368899, Oxytocin, 2641, Tocris Bioscience

4 Citations for L-368,899 hydrochloride

Citations are publications that use Tocris products. Selected citations for L-368,899 hydrochloride include:

Pont et al (2012) Oxytocin-stimulated NFAT transcriptional activation in human myometrial cells. Mol.Endocrinol. 26 1743 PMID: 22902539

Gaetani et al (2010) The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxyt. Nat Commun 30 8096 PMID: 20554860

Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731

Xiao et al (2017) Biased OXTergic Modulation of Midbrain DA Systems. Neuron 95 368 PMID: 28669546

Do you know of a great paper that uses L-368,899 hydrochloride from Tocris? Please let us know.

Reviews for L-368,899 hydrochloride

Average Rating: 5 (Based on 1 Review.)

5 Star
4 Star
3 Star
2 Star
1 Star

Have you used L-368,899 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:

Works as expected..
By Anonymous on 05/26/2020
Assay Type: Ex Vivo
Species: Mouse

We performed ex-vivo slice physiology, and bath applied L-368,899 hydrochloride.

PMID: 32133707
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

GPCR Product Listing

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

  • Anterior Pituitary Regulation
  • Blood Pressure Regulation
  • Feeding and Appetite Regulation
  • Glucose Regulation
  • Peptide Hormone Processing