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Oxytocin is a neurohypophyseal peptide. Stimulates uterine contraction and lactation.
(Modifications: Gly-9 = C-terminal amide, Disulfide bridge between 1 - 6)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 1 mg/ml in water|
References are publications that support the biological activity of the product.
Barberis and Tribolle (1996) Vasopressin and oxyt. receptors in the central nervous system. Crit.Rev.Neurobiol. 10 119 PMID: 8853957
Thibonnier et al (1998) Signal transduction pathways of the human V1-vascular V2-renal, V3-pituitary vasopressin and oxyt. receptors. Prog.Brain Res. 119 147 PMID: 10074787
If you know of a relevant reference for Oxytocin, please let us know.
Keywords: Oxytocin, Oxytocin supplier, Involved, uterine, contraction, lactation, OT, Receptors, agonists, Oxytocin, 1910, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Oxytocin include:
Rapanelli et al (2017) Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biol Psychiatry 82 194 PMID: 28347488
Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541
Ferreira et al (2019) OXT can regulate myometrial smooth muscle excitability by inhibiting the Na+ -activated K+ channel, Slo2.1. J Physiol 597 137 PMID: 30334255
Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731
Spaethling et al (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. Hypertension 28 771 PMID: 24192459
Brierley et al (2021) Central and peripheral GLP-1 systems independently and additively suppress eating. Nat Metab 3 258 PMID: 33589843
Do you know of a great paper that uses Oxytocin from Tocris? Please let us know.
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Used to stimulate gut smooth muscle contraction from rats at concentrations of 10-9 to 10-5
Preincubation of slices in oxytocin (200 nM) resulted in an increase in holding current when compared to slices incubated in normal ACSF.
Applied to rat uterus and human smooth muscle
Do not freeze thaw
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