Pricing Availability   Qty
Description: Involved in uterine contraction and lactation
Citations (6)
Reviews (3)
Literature (2)

Biological Activity for Oxytocin

Oxytocin is a neurohypophyseal peptide. Stimulates uterine contraction and lactation.

Technical Data for Oxytocin

M. Wt 1007.19
Formula C43H66N12O12S2

(Modifications: Gly-9 = C-terminal amide, Disulfide bridge between 1 - 6)

Storage Desiccate at -20°C
CAS Number 50-56-6
PubChem ID 439302
Smiles [H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)[C@@H](C)CC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Oxytocin

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Oxytocin

Certificate of Analysis / Product Datasheet
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References for Oxytocin

References are publications that support the biological activity of the product.

Barberis and Tribolle (1996) Vasopressin and oxyt. receptors in the central nervous system. Crit.Rev.Neurobiol. 10 119 PMID: 8853957

Thibonnier et al (1998) Signal transduction pathways of the human V1-vascular V2-renal, V3-pituitary vasopressin and oxyt. receptors. Prog.Brain Res. 119 147 PMID: 10074787

If you know of a relevant reference for Oxytocin, please let us know.

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Keywords: Oxytocin, Oxytocin supplier, Involved, uterine, contraction, lactation, OT, Receptors, agonists, Oxytocin, 1910, Tocris Bioscience

6 Citations for Oxytocin

Citations are publications that use Tocris products. Selected citations for Oxytocin include:

Rapanelli et al (2017) Targeted Interneuron Depletion in the Dorsal Striatum Produces Autism-like Behavioral Abnormalities in Male but Not Female Mice. Biol Psychiatry 82 194 PMID: 28347488

Nøhr et al (2017) The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW. Neurochem Int 102 105 PMID: 27916541

Ferreira et al (2019) OXT can regulate myometrial smooth muscle excitability by inhibiting the Na+ -activated K+ channel, Slo2.1. J Physiol 597 137 PMID: 30334255

Xiao et al (2018) OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons. Elife 7 PMID: 29676731

Spaethling et al (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. Hypertension 28 771 PMID: 24192459

Brierley et al (2021) Central and peripheral GLP-1 systems independently and additively suppress eating. Nat Metab 3 258 PMID: 33589843

Do you know of a great paper that uses Oxytocin from Tocris? Please let us know.

Reviews for Oxytocin

Average Rating: 4.7 (Based on 3 Reviews.)

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Stimulation of gut smooth muscle.
By Mohammad Alqudah on 10/19/2022
Assay Type: Ex Vivo
Species: Rat
Cell Line/Tissue: Smooth muscle

Used to stimulate gut smooth muscle contraction from rats at concentrations of 10-9 to 10-5

review image

Works as expected..
By Anonymous on 06/01/2020
Assay Type: Ex Vivo
Species: Mouse
Cell Line/Tissue: Paraventricular nucleus of hypothalamus

Preincubation of slices in oxytocin (200 nM) resulted in an increase in holding current when compared to slices incubated in normal ACSF.

PMID: 32133707
review image

Applied to smooth muscle in tissue bath.
By John Broad on 01/05/2018
Species: Rat

Applied to rat uterus and human smooth muscle

Do not freeze thaw

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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