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Biological Activity for PD 334581
PD 334581 is an inhibitor of MEK1. Analog of PD 184352 (Cat. No. 4237).
Technical Data for PD 334581
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PD 334581
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for PD 334581
The following data is based on the product molecular weight 545.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.83 mL||9.17 mL||18.34 mL|
|5 mM||0.37 mL||1.83 mL||3.67 mL|
|10 mM||0.18 mL||0.92 mL||1.83 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References for PD 334581
References are publications that support the biological activity of the product.
Zhang et al (2009) Targeting cancer with small molecule kinase inhibitors. Nat.Rev.Cancer 9 28 PMID: 19104514
Ohren et al (2004) Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel competitive kinase inhibition. Nat.Struct.Mol.Biol. 11 1192 PMID: 15543157
If you know of a relevant reference for PD 334581, please let us know.
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Keywords: PD 334581, PD 334581 supplier, PD334581, MEK1, kinase, inhibitors, inhibits, mitogen, activated, protein, 1, MEK, 4824, Tocris Bioscience
Citations for PD 334581
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.