You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Inhibitor of MEK1. Analog of PD 184352 (Cat. No. 4237).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 545.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.83 mL||9.17 mL||18.34 mL|
|5 mM||0.37 mL||1.83 mL||3.67 mL|
|10 mM||0.18 mL||0.92 mL||1.83 mL|
|50 mM||0.04 mL||0.18 mL||0.37 mL|
References are publications that support the biological activity of the product.
Zhang et al (2009) Targeting cancer with small molecule kinase inhibitors. Nat.Rev.Cancer 9 28 PMID: 19104514
Ohren et al (2004) Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel competitive kinase inhibition. Nat.Struct.Mol.Biol. 11 1192 PMID: 15543157
If you know of a relevant reference for PD 334581, please let us know.
View Related Products by Product Action
Keywords: PD 334581, PD 334581 supplier, PD334581, MEK1, kinase, inhibitors, inhibits, mitogen, activated, protein, 1, MEK, 4824, Tocris Bioscience
Citations for PD 334581
Citations are publications that use Tocris products.
Currently there are no citations for PD 334581. Do you know of a great paper that uses PD 334581 from Tocris? Please let us know.
Reviews for PD 334581
There are currently no reviews for this product. Be the first to review PD 334581 and earn rewards!
Have you used PD 334581?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.