I1 Receptors

Imidazoline 1 receptors (I1) are members of the imidazoline family of receptors, which also include I2 and I3 receptors. I1 receptors are localized to the plasma membrane and are found in the lateral reticular nucleus, locus coeruleus, kidney, pancreas and on platelets.

Products
Background
Literature
Gene Data

Agonists

Cat No Product Name / Activity
0902 Cimetidine
I1 agonist. Also histamine H2 antagonist
2282 Moxonidine hydrochloride
I1 receptor and α2-adrenoceptor agonist (I1 > α2)

Other

Cat No Product Name / Activity
1072 AGN 192403 hydrochloride
I1 selective ligand
0690 Clonidine hydrochloride
I1 ligand. Also α2 agonist
0790 Rilmenidine hemifumarate
I1 ligand. Also α2 agonist

Imidazoline 1 receptors (I1) (labeled by clonidine) are members of the imidazoline family of receptors, which also include I2 (labeled by idazoxan) and I3 receptors. I1 receptors are localized to the plasma membrane and are found in the lateral reticular nucleus, locus coeruleus, kidney, pancreas and on platelets.

I1 activation is coupled to choline phospholipid hydrolysis, leading to the generation of diacylglyceride, arachidonic acid and eicosanoids. Also, I1 may inhibit the Na+,H+ exchanger.

Physiological roles of the I1 receptor include lowering blood pressure, renal osmolar clearance, central control of intraocular pressure and the electrophysiological response to hypoxia.

Literature for I1 Receptors

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

I1 Receptor Gene Data

Species Gene Symbol Gene Accession No. Protein Accession No.
Human NISCH NM_007184 Q9Y2I1
Mouse Nisch NM_022656 Q80TM9
Rat Nisch XM_240330 Q4G017