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Endogenous free fatty acid released from phospholipids by phospholipase A2, in water-soluble emulsion (for details see TocrisolveTM 100, Cat. No. 1684). Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.
Tocrisolve Control also available.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Nakanishi et al (2006) Roles of cPLA2α and arachidonic acid in cancer. Biochim.Biophys.Acta 1761 1335 PMID: 17052951
Levick et al (2007) Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation. J.Immunol. 178 641 PMID: 17202322
Higuchi et al (2007) Arachidonic acid promotes glutamate-induced cell death associated with necrosis by 12-lipoxygenase activation in glioma cells. Life Sci. 80 1856 PMID: 17400255
Keywords: Arachidonic acid (in Tocrisolve 100), Arachidonic acid (in Tocrisolve 100) supplier, Endogenous, free, fatty, acid, water-soluble, emulsion, Lipid, Metabolism, Prostanoid, eicosanoid, receptors, leukotrienes, eicosanoids, prostaglandins, prostacyclins, Leukotriene, and, Related, Receptors, Other, 2756, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Arachidonic acid (in Tocrisolve™100) include:
Hamtiaux et al (2011) Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. PLoS One 6 e26823 PMID: 22046372
Park et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat Immunol 17 914 PMID: 27270401
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