I2 Receptors

Imidazoline 2 receptors (I2) are members of the imidazoline receptor family, which includes I1 and I3 receptors. I2 receptors are localized to the mitochondrial membrane and are found in the arcuate nucleus, pineal gland, heart, kidney, white adipocytes and striated muscle.

Products
Background
Literature
Cat No Product Name / Activity
0890 Amiloride hydrochloride
I2 selective ligand, differentiates I2A and I2B; also Na+ channel blocker
0348 2-BFI hydrochloride
Potent, selective I2 ligand. Putative agonist
0725 BU 224 hydrochloride
Potent, selective I2 ligand. Putative antagonist
1091 BU 226 hydrochloride
Potent, highly selective I2 ligand
0726 BU 239 hydrochloride
Potent, highly selective I2 ligand
0885 Guanabenz acetate
I2 selective ligand. Also α2 agonist
0793 Idazoxan hydrochloride
I2 ligand, α2 antagonist
0889 RS 45041-190 hydrochloride
High affinity I2 ligand. Highly selective

Imidazoline 2 receptors (I2) (labeled by idazoxan) are members of the imidazoline family of receptors, which also include I1 (labeled by clonidine) and I3 receptors. I2 receptors are localized to the mitochondrial membrane and are found in the interpeduncular nucleus, arcuate nucleus, pineal gland, liver, heart, kidney, white adipocytes and striated muscle. Furthermore, I2 receptors constitute an allosteric binding site of monoamine oxidase (MAO) A and MAO-B.

Little is known about the transduction mechanism of I2 receptors and the gene encoding it has not yet been characterized.

Literature for I2 Receptors

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells