I2 Receptors

Imidazoline 2 receptors (I2) are members of the imidazoline receptor family, which includes I1 and I3 receptors. I2 receptors are localized to the mitochondrial membrane and are found in the arcuate nucleus, pineal gland, heart, kidney, white adipocytes and striated muscle.

Products
Background
Cat. No. Product Name / Activity
0890 Amiloride hydrochloride
I2 selective ligand, differentiates I2A and I2B; also Na+ channel blocker
0348 2-BFI hydrochloride
Potent, selective I2 ligand. Putative agonist
0725 BU 224 hydrochloride
Potent, selective I2 ligand. Putative antagonist
0726 BU 239 hydrochloride
Potent, highly selective I2 ligand
0885 Guanabenz acetate
I2 selective ligand. Also α2 agonist
0793 Idazoxan hydrochloride
I2 ligand, α2 antagonist

Imidazoline 2 receptors (I2) (labeled by idazoxan) are members of the imidazoline family of receptors, which also include I1 (labeled by clonidine) and I3 receptors. I2 receptors are localized to the mitochondrial membrane and are found in the interpeduncular nucleus, arcuate nucleus, pineal gland, liver, heart, kidney, white adipocytes and striated muscle. Furthermore, I2 receptors constitute an allosteric binding site of monoamine oxidase (MAO) A and MAO-B.

Little is known about the transduction mechanism of I2 receptors and the gene encoding it has not yet been characterized. Studies suggest a role for I2 receptors in Alzheimer's disease, depression and pain.