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Submit ReviewIdazoxan hydrochloride
Discontinued Product
Idazoxan hydrochloride (Cat. No. 0793) has been withdrawn from sale for commercial reasons.
Description: α2 antagonist. Also I2 ligand
Alternative Names: RX 781094
Chemical Name: 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride
Purity: ≥98%
Biological Activity for Idazoxan hydrochloride
Idazoxan hydrochloride is a α2-adrenoceptor antagonist, and I2 ligand, selective over I1 sites (pKi values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I1, I2, α2A, α2B, and α2C receptors respectively).
Technical Data for Idazoxan hydrochloride
| M. Wt | 240.69 |
| Formula | C11H12N2O2.HCl |
| Storage | Store at RT |
| Purity | ≥98% |
| CAS Number | 79944-56-2 |
| PubChem ID | 154494 |
| InChI Key | MYUBYOVCLMEAOH-UHFFFAOYSA-N |
| Smiles | Cl.C1CN=C(N1)C1COC2=CC=CC=C2O1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Idazoxan hydrochloride
References for Idazoxan hydrochloride
References are publications that support the biological activity of the product.
Berdeu et al (1995) Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur.J.Pharmacol. 275 91 PMID: 7774667
Dabir (1986) Idazoxan: a novel pharmacological tool for the study of α2-adrenoceptors. J.Pharmacol. 17 113 PMID: 2875218
Eglen et al (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 19 381 PMID: 9786027
Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TIPS 13 369 PMID: 1413085
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2 Citations for Idazoxan hydrochloride
Citations are publications that use Tocris products. Selected citations for Idazoxan hydrochloride include:
Bucher et al (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037
Sadeghi et al (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapen. in rat single locus coeruleus neurons. Development 172 460 PMID: 24372103
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