Idazoxan hydrochloride

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Cat.No. 0793 - Idazoxan hydrochloride | C11H12N2O2.HCl | CAS No. 79944-56-2
Description: α2 antagonist. Also I2 ligand
Alternative Names: RX 781094
Chemical Name: 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride
Purity: ≥98%
Datasheet
Citations (2)
Reviews
Literature

Biological Activity

α2-adrenoceptor antagonist, and I2 ligand, selective over I1 sites (pKi values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I1, I2, α2A, α2B, and α2C receptors respectively).

Technical Data

M. Wt 240.69
Formula C11H12N2O2.HCl
Storage Store at RT
Purity ≥98%
CAS Number 79944-56-2
PubChem ID 154494
InChI Key MYUBYOVCLMEAOH-UHFFFAOYSA-N
Smiles Cl.C1CN=C(N1)C1COC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.07 100
phosphate buffered saline 12.03 50

Preparing Stock Solutions

The following data is based on the product molecular weight 240.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.15 mL 20.77 mL 41.55 mL
5 mM 0.83 mL 4.15 mL 8.31 mL
10 mM 0.42 mL 2.08 mL 4.15 mL
50 mM 0.08 mL 0.42 mL 0.83 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Berdeu et al (1995) Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur.J.Pharmacol. 275 91 PMID: 7774667

Dabir (1986) Idazoxan: a novel pharmacological tool for the study of α2-adrenoceptors. J.Pharmacol. 17 113 PMID: 2875218

Eglen et al (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 19 381 PMID: 9786027

Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TIPS 13 369 PMID: 1413085


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2 Citations for Idazoxan hydrochloride

Citations are publications that use Tocris products. Selected citations for Idazoxan hydrochloride include:

Sadeghi et al (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons. Development 172 460 PMID: 24372103

Bucher et al (2014) Medullary norepinephrine neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037


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