Idazoxan hydrochloride

Discontinued Product

Idazoxan hydrochloride (Cat. No. 0793) has been withdrawn from sale for commercial reasons.
Description: α2 antagonist. Also I2 ligand
Alternative Names: RX 781094
Chemical Name: 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride
Purity: ≥98%
Citations (2)
Literature (2)

Biological Activity for Idazoxan hydrochloride

Idazoxan hydrochloride is a α2-adrenoceptor antagonist, and I2 ligand, selective over I1 sites (pKi values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I1, I2, α2A, α2B, and α2C receptors respectively).

Technical Data for Idazoxan hydrochloride

M. Wt 240.69
Formula C11H12N2O2.HCl
Storage Store at RT
Purity ≥98%
CAS Number 79944-56-2
PubChem ID 154494
Smiles Cl.C1CN=C(N1)C1COC2=CC=CC=C2O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Idazoxan hydrochloride

Certificate of Analysis / Product Datasheet
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References for Idazoxan hydrochloride

References are publications that support the biological activity of the product.

Berdeu et al (1995) Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur.J.Pharmacol. 275 91 PMID: 7774667

Dabir (1986) Idazoxan: a novel pharmacological tool for the study of α2-adrenoceptors. J.Pharmacol. 17 113 PMID: 2875218

Eglen et al (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 19 381 PMID: 9786027

Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TIPS 13 369 PMID: 1413085

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2 Citations for Idazoxan hydrochloride

Citations are publications that use Tocris products. Selected citations for Idazoxan hydrochloride include:

Sadeghi et al (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapen. in rat single locus coeruleus neurons. Development 172 460 PMID: 24372103

Bucher et al (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

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