NS 398

Pricing Availability   Qty
Description: Cyclooxygenase-2 (COX-2) inhibitor
Chemical Name: N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations (14)
Reviews
Literature (2)

Biological Activity for NS 398

NS 398 is a selective cyclooxygenase-2 inhibitor (IC50 values are 3.8 and > 100 μM for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro. Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo.

Compound Libraries for NS 398

NS 398 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NS 398

M. Wt 314.36
Formula C13H18N2O5S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 123653-11-2
PubChem ID 4553
InChI Key KTDZCOWXCWUPEO-UHFFFAOYSA-N
Smiles CS(=O)(=O)NC1=C(OC2CCCCC2)C=C(C=C1)[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NS 398

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.44 100

Preparing Stock Solutions for NS 398

The following data is based on the product molecular weight 314.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.18 mL 15.91 mL 31.81 mL
5 mM 0.64 mL 3.18 mL 6.36 mL
10 mM 0.32 mL 1.59 mL 3.18 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for NS 398

References are publications that support the biological activity of the product.

Elder et al (2002) The MEK/ERK pathway mediates COX-2-selective NSAID-induced apoptosis and induced COX-2 protein expression in colorectal carcinoma cells. Int.J.Cancer 99 323 PMID: 11992399

Futaki et al (1993) NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen.Pharmacol. 24 105 PMID: 8482483

Futaki et al (1994) NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins 47 55 PMID: 8140262


If you know of a relevant reference for NS 398, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Cyclooxygenase Inhibitors

Keywords: NS 398, NS 398 supplier, Cyclooxygenase, COX-2, inhibitors, inhibits, COX, Oxygenases, Oxidases, NS398, 0942, Tocris Bioscience

14 Citations for NS 398

Citations are publications that use Tocris products. Selected citations for NS 398 include:

Tunaru et al (2016) Arachidonic acid metabolite 19(S)-HETE induces vasorelaxation and platelet inhibition by activating prostacyclin(IP) receptor. PLoS One 11 e0163633 PMID: 27662627

Liu et al (2014) Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress. Antioxid Redox Signal 21 1571 PMID: 24328731

Buenestado et al (2012) Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide. Br J Pharmacol 165 1877 PMID: 21913898

Sunters et al (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i J Biol Chem 285 8743 PMID: 20042609

Bonfill-Teixidor et al (2017) Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide. J Neuroinflammation 14 3 PMID: 28086956

Bourquin et al (2011) Systemic cancer therapy with a small molecule agonist of toll-like receptor 7 can be improved by circumventing TLR tolerance. Cancer Res 71 5123 PMID: 21697281

Chia et al (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol 11 10 PMID: 21955547

Sugiyama et al (2013) The cyclooxygenase-2 selective inhibitor NS-398 does not influence trabecular or cortical bone gain resulting from repeated mechanical loading in female mice. Osteoporos Int 24 383 PMID: 22349912

Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228 PMID: 19096033

Messerschmidt et al (2019) Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation. Mol Vis 25 329 PMID: 31341381

Wei et al (2015) Proinflammatory cytokines upregulate sympathoexcitatory mechanisms in the subfornical organ of the rat. Hypertension 65 1126 PMID: 25776070

Font-Nieves et al (2012) Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes. J Biol Chem 287 6454 PMID: 22219191

Ho et al (2015) Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. J Virol 22 46 PMID: 26100815

Ray et al (2004) Cyclooxygenase-1 and -2 are required for production of infectious pseudorabies virus. PLoS One 78 12964 PMID: 15542648


Do you know of a great paper that uses NS 398 from Tocris? Please let us know.

Reviews for NS 398

There are currently no reviews for this product. Be the first to review NS 398 and earn rewards!

Have you used NS 398?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.