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Submit ReviewDiclofenac sodium salt
Description: Cyclooxygenase inhibitor; NSAID
Chemical Name: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Purity: ≥99% (HPLC)
Biological Activity for Diclofenac sodium salt
Diclofenac sodium salt is a nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC50 values are 0.075 μM for COX-1 and 0.038 μM for COX-2 in human whole blood assay).
Technical Data for Diclofenac sodium salt
| M. Wt | 318.13 |
| Formula | C14H10Cl2NNaO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 15307-79-6 |
| PubChem ID | 5018304 |
| InChI Key | KPHWPUGNDIVLNH-UHFFFAOYSA-M |
| Smiles | [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Diclofenac sodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.91 | 50 | |
| DMSO | 31.81 | 100 |
Preparing Stock Solutions for Diclofenac sodium salt
The following data is based on the product molecular weight 318.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.14 mL | 15.72 mL | 31.43 mL |
| 5 mM | 0.63 mL | 3.14 mL | 6.29 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.14 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets for Diclofenac sodium salt
References for Diclofenac sodium salt
References are publications that support the biological activity of the product.
Warner et al (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc.Natl.Acad.Sci.USA 96 7563 PMID: 10377455
Bort et al (1998) Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. J.Pharmacol.Exp.Ther. 288 65 PMID: 9862754
Laneuville et al (1994) Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J.Pharmacol.Exp.Ther. 271 927 PMID: 7965814
If you know of a relevant reference for Diclofenac sodium salt, please let us know.
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Keywords: Diclofenac sodium salt, Diclofenac sodium salt supplier, nsaids, non-steroidal, anti-inflammatories, anti-inflammatory, cox-1, cox-2, cyclooxygenase, inhibitors, inhibits, Cyclooxygenase, 4454, Tocris Bioscience
1 Citation for Diclofenac sodium salt
Citations are publications that use Tocris products. Selected citations for Diclofenac sodium salt include:
Timothy S et al (2021) Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells. J Immunol 207 1275-1287 PMID: 34389624
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