Diclofenac sodium salt

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Cat.No. 4454 - Diclofenac sodium salt | C14H10Cl2NNaO2 | CAS No. 15307-79-6
Description: Cyclooxygenase inhibitor; NSAID
Chemical Name: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC50 values are 0.075 μM for COX-1 and 0.038 μM for COX-2 in human whole blood assay).

Technical Data

M. Wt 318.13
Formula C14H10Cl2NNaO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 15307-79-6
PubChem ID 5018304
InChI Key KPHWPUGNDIVLNH-UHFFFAOYSA-M
Smiles [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.81 100
ethanol 31.81 100
water 15.91 50

Preparing Stock Solutions

The following data is based on the product molecular weight 318.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.72 mL 31.43 mL
5 mM 0.63 mL 3.14 mL 6.29 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Warner et al (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc.Natl.Acad.Sci.USA 96 7563 PMID: 10377455

Bort et al (1998) Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. J.Pharmacol.Exp.Ther. 288 65 PMID: 9862754

Laneuville et al (1994) Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J.Pharmacol.Exp.Ther. 271 927 PMID: 7965814


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Citations for Diclofenac sodium salt

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