Diclofenac sodium salt

Pricing Availability   Qty
Description: Cyclooxygenase inhibitor; NSAID
Chemical Name: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Purity: ≥99% (HPLC)
Citations (1)
Literature (2)

Biological Activity for Diclofenac sodium salt

Diclofenac sodium salt is a nonsteroidal, anti-inflammatory drug (NSAID); inhibits COX-1 and COX-2 (IC50 values are 0.075 μM for COX-1 and 0.038 μM for COX-2 in human whole blood assay).

Technical Data for Diclofenac sodium salt

M. Wt 318.13
Formula C14H10Cl2NNaO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 15307-79-6
PubChem ID 5018304
Smiles [Na+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Diclofenac sodium salt

Solvent Max Conc. mg/mL Max Conc. mM
water 15.91 50
DMSO 31.81 100

Preparing Stock Solutions for Diclofenac sodium salt

The following data is based on the product molecular weight 318.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.72 mL 31.43 mL
5 mM 0.63 mL 3.14 mL 6.29 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets for Diclofenac sodium salt

References for Diclofenac sodium salt

References are publications that support the biological activity of the product.

Warner et al (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc.Natl.Acad.Sci.USA 96 7563 PMID: 10377455

Bort et al (1998) Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. J.Pharmacol.Exp.Ther. 288 65 PMID: 9862754

Laneuville et al (1994) Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J.Pharmacol.Exp.Ther. 271 927 PMID: 7965814

If you know of a relevant reference for Diclofenac sodium salt, please let us know.

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Keywords: Diclofenac sodium salt, Diclofenac sodium salt supplier, nsaids, non-steroidal, anti-inflammatories, anti-inflammatory, cox-1, cox-2, cyclooxygenase, inhibitors, inhibits, Cyclooxygenase, 4454, Tocris Bioscience

1 Citation for Diclofenac sodium salt

Citations are publications that use Tocris products. Selected citations for Diclofenac sodium salt include:

Timothy S et al (2021) Differential Regulation of ATP- and UTP-Evoked Prostaglandin E2 and IL-6 Production from Human Airway Epithelial Cells. J Immunol 207 1275-1287 PMID: 34389624

Do you know of a great paper that uses Diclofenac sodium salt from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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