Valdecoxib

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Cat.No. 4206 - Valdecoxib | C16H14N2O3S | CAS No. 181695-72-7
Description: Selective and potent COX-2 inhibitor
Chemical Name: 4-(5-Methyl-3-phenylisoxazol-4-yl)benzenesulfonamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective and potent COX-2 inhibitor (in vitro IC50 values are 0.005 and 140 μM for human recombinant COX-2 and COX-1 respectively). Displays potent anti-inflammatory activity in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

Valdecoxib is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 314.36
Formula C16H14N2O3S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 181695-72-7
PubChem ID 119607
InChI Key LNPDTQAFDNKSHK-UHFFFAOYSA-N
Smiles CC1=C(C3=CC=C(S(=O)(N)=O)C=C3)C(C2=CC=CC=C2)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 314.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.18 mL 15.91 mL 31.81 mL
5 mM 0.64 mL 3.18 mL 6.36 mL
10 mM 0.32 mL 1.59 mL 3.18 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Talley et al (2000) 4-[5-methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2. J.Med.Chem. 43 775 PMID: 10715145

Walker et al (2001) A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors. Biochem.J. 357 709 PMID: 11463341

Gierse et al (2005) Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity. J.Pharmacol.Exp.Ther. 312 1206 PMID: 15494548


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Keywords: Valdecoxib, supplier, cyclooxygenase-2, COX-2, inhibitors, inhibits, selective, potent, NSAIDs, pfizer, non-steroidal, anti-inflammatory, Cyclooxygenase, Cyclooxygenase, Tocris Bioscience

Citations for Valdecoxib

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